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Whereas osmolality (with an "l") is defined as the number of osmoles (Osm) of solute per kilogram of solvent (osmol/kg or Osm/kg), osmolarity (with an "r") is defined as the number of osmoles of solute per liter (L) of solution (osmol/L or Osm/L). As such, larger numbers indicate a greater concentration of solutes in the plasma.
Osmotic concentration, formerly known as osmolarity, [1] is the measure of solute concentration, defined as the number of osmoles (Osm) of solute per litre (L) of solution (osmol/L or Osm/L). The osmolarity of a solution is usually expressed as Osm/L (pronounced "osmolar"), in the same way that the molarity of a solution is expressed as "M ...
Urine osmolality in humans can range from approximately 50 to 1200 mOsm/kg, depending on whether the person has recently drunk a large quantity of water (the lower number) or has gone without water for a long time (the higher number). [2] Plasma osmolality with typical fluid intake often averages approximately 290 mOsm/kg H 2 O in humans. [2]
Normal serum osmolality ranges from 280 to 290 mOsm/kg and serum osmolality to cause water removal from brain without much side effects ranges from 300 to 320 mOsm/kg. Usually, 90 mL of space is created in the intracranial vault by 1.6% reduction in brain water content. [1] Osmotherapy has cerebral dehydrating effects. [2]
[2] 290 mOsm/kg is the presumed stool osmolality, and the measured concentration of sodium and potassium cations is doubled to account for the corresponding anions which must be present. [citation needed] A normal gap is between 50 and 100 mOsm/kg, [3] corresponding to the concentration of other solutes such as magnesium salts and sugars ...
The proposed mechanism consists of pump, equilibration, and shift steps. In the proximal tubule, the osmolarity is isomolar to plasma (300 mOsm/L). In a hypothetical model where there was no equilibration or pump steps, the tubular fluid and interstitial osmolarity would be 300 mOsm/L as well.{Respicius Rwehumbiza, 2010}
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Osmolality – ideally isotonic (~300 mOsm/kg); although hyptertonicity allows reduced volume of injection, an upper limit (~600 mOsm/kg) is advised to minimize hypertonicity-induced pain [3] Viscosity – lower viscosity leads to more pain
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