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[1] [2] When the iodine atom is a radioactive isotope (iodine-125 or iodine-131), it is used as an adrenal cortex radiotracer in the diagnosis of patients suspected of having Cushing's syndrome, hyperaldosteronism, [3] pheochromocytoma, and adrenal remnants following total adrenalectomy. [1] [2]
Iodine-131 (131 I, I-131) is an important radioisotope of iodine discovered by Glenn Seaborg and John Livingood in 1938 at the University of California, Berkeley. [3] It has a radioactive decay half-life of about eight days. It is associated with nuclear energy, medical diagnostic and treatment procedures, and natural gas production.
Another well-known radioactive isotope used in medicine is Iodine-131, which is used as a radioactive label for some radiopharmaceutical therapies or the treatment of some types of thyroid cancer. [ 2 ]
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There is also an oral capsule that contains the oil, equivalent to 190 mg iodine. [18] [19] Iodized poppyseed oil (Lipiodol) given orally or intermuscularly produces a long-lasting store of iodine in the body, allowing very infrequent dosing. Iodized oil is a cost-effective way of combating iodine deficiency.
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Iodine-131 (131 I) is the most common RNT worldwide and uses the simple compound sodium iodide with a radioactive isotope of iodine. The patient (human or animal) may ingest an oral solid or liquid amount or receive an intravenous injection of a solution of the compound. The iodide ion is selectively taken up by the thyroid gland.
Iodine-131, a radioactive isotope used for thyroid imaging (scintigraphy) and therapy of thyroid cancers, can be less effective when used within two to six weeks after application of iotrolan because of residual iodine in the body. Iotrolan can slow down the excretion of the diabetes drug metformin, potentially resulting in lactic acidosis. [2]
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