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Conditions included in this group are: [1] [2] Acral dry gangrene; Carotenosis; Diabetic dermopathy; Diabetic bulla; Diabetic cheiroarthropathy; Malum perforans; Necrobiosis lipoidica; Limited joint mobility is observed in roughly 30% of people with diabetes with longstanding disease. [1] Scleredema; Waxy skin is observed in roughly 50%. [1]
It is the most common [1]: 540 [2]: 681 of several diabetic skin conditions, being found in up to 30% of diabetics. Similar lesions can occasionally be found in non-diabetics usually following trauma or injury to the area; however, more than 4 lesions strongly suggests diabetes.
Necrobiosis lipoidica is a rare, chronic skin condition predominantly associated with diabetes mellitus (known as necrobiosis lipoidica diabeticorum or NLD). [1] It can also occur in individuals with rheumatoid arthritis or without any underlying conditions ( idiopathic ). [ 2 ]
Dermopathy can refer to one of several diseases: Diabetic dermopathy; Graves' dermopathy, or infiltrative dermopathy; Nephrogenic fibrosing dermopathy (NFD)
Diabetic cheiroarthropathy, also known as diabetic stiff hand syndrome or limited joint mobility syndrome, is a cutaneous condition characterized by waxy, thickened skin and limited joint mobility of the hands and fingers, leading to flexion contractures, a condition associated with diabetes mellitus [1]: 681 and it is observed in roughly 30% of diabetic patients with longstanding disease.
Metformin is a drug used in humans for type II diabetes, and has been shown to improve insulin sensitivity and reduce output of glucose by the liver. [24] However, it has low bioavailability in horses, [ 25 ] and does not appear to affect insulin sensitivity at doses that are commonly used. [ 26 ]
The biopsy is stained for glycogen, and the intensity of stain uptake in the muscle, as well as the presence of any inclusions, helps to determine the diagnosis of PSSM. This test is the only method for diagnosing Type 2 PSSM. Horses with Type 1 PSSM will usually have between 1.5-2 times the normal levels of glycogen in their skeletal muscle. [10]
A diabetic bulla, also known as bullosis diabeticorum, or bullous eruption of diabetes mellitus, is a cutaneous condition characterized by a noninflammatory, spontaneous, painless blister, often in acral locations (peripheral body parts, such as feet, toes, hands, fingers, ears or nose), seen in diabetic patients. [2] [3]: 681 [3]: 467–8