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  2. Trifluoromethyl group - Wikipedia

    en.wikipedia.org/wiki/Trifluoromethyl_group

    Trifluoromethyl group covalently bonded to an R group. The trifluoromethyl group is a functional group that has the formula-CF 3. The naming of is group is derived from the methyl group (which has the formula -CH 3), by replacing each hydrogen atom by a fluorine atom. Some common examples are trifluoromethane H– CF 3, 1,1,1-trifluoroethane H ...

  3. Trifluoromethylation - Wikipedia

    en.wikipedia.org/wiki/Trifluoromethylation

    The first to investigate trifluoromethyl groups in relationship to biological activity was F. Lehmann in 1927. [5] An early review appeared in 1958. [6] An early synthetic method was developed by Frédéric Swarts in 1892, [7] based on antimony fluoride.

  4. Trifluoromethyltrimethylsilane - Wikipedia

    en.wikipedia.org/wiki/Trifluoromethyltrimethylsilane

    Trifluoromethyltrimethylsilane (known as Ruppert-Prakash reagent, TMSCF 3) is an organosilicon compound with the formula CF 3 Si(CH 3) 3.It is a colorless liquid. The compound is a reagent used in organic chemistry for the introduction of the trifluoromethyl group.

  5. Trifluoromethoxy group - Wikipedia

    en.wikipedia.org/wiki/Trifluoromethoxy_group

    Trifluoromethoxy group. The trifluoromethoxy group is the chemical group –O– CF 3.It can be seen as a methoxy group –O– CH 3 whose hydrogen atoms are replaced by fluorine atoms; or as a trifluoromethyl group attached to the rest of the molecule by a bridging oxygen atom; either leads to viable syntheses. [1]

  6. 4-Trifluoromethylbenzaldehyde - Wikipedia

    en.wikipedia.org/wiki/4-Trifluoromethylbenzaldehyde

    Two other isomers are also known: 2-trifluoromethylbenzaldehyde and 3-trifluoromethylbenzaldehyde. These compounds are derivatives of benzaldehyde with trifluoromethyl substituents. The CF 3 group enhances the electrophilicity of the formyl group and provides a label for analysis by fluorine-19 nuclear magnetic resonance spectroscopy.

  7. Organofluorine chemistry - Wikipedia

    en.wikipedia.org/wiki/Organofluorine_chemistry

    Their strong acidity is attributed to the electronegativity of the trifluoromethyl group that stabilizes the negative charge. The triflate-group (the conjugate base of the triflic acid) is a good leaving group in substitution reactions. Fluorocarbon substituents can enhance the Lewis acidity of metal centers.

  8. Category:Trifluoromethyl compounds - Wikipedia

    en.wikipedia.org/wiki/Category:Trifluoromethyl...

    Pages in category "Trifluoromethyl compounds" The following 200 pages are in this category, out of approximately 420 total. This list may not reflect recent changes .

  9. Flufenamic acid - Wikipedia

    en.wikipedia.org/wiki/Flufenamic_acid

    [8] [9] A fundamental feature of the structure of flufenamic acid, which has generated significant interest in the design and development of drugs, [10] is the presence of a trifluoromethyl group. Compounds with fluorine-containing substituents are known to have promising chemical and biological properties, [ 11 ] [ 12 ] since such groups often ...