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The protein was first named as CRMP-62 having a relative molecular mass of 62 kDa and later referred as CRMP-2. Concurrently, a 64 kDa protein named as TOAD-64 for Turned On After Division, was shown to increase significantly during the development of the cortex of the brain. The cDNA sequence of TOAD-64 corresponded to that of rat CRMP-2.
Arc protein is widely considered to be important in neurobiology because of its activity regulation, localization, and utility as a marker for plastic changes in the brain. Dysfunction in the production of Arc protein has been implicated as an important factor in understanding various neurological conditions, including amnesia , [ 9 ] Alzheimer ...
Molecular neuroscience is a branch of neuroscience that observes concepts in molecular biology applied to the nervous systems of animals. The scope of this subject covers topics such as molecular neuroanatomy, mechanisms of molecular signaling in the nervous system, the effects of genetics and epigenetics on neuronal development, and the molecular basis for neuroplasticity and ...
Two molecular mechanisms for synaptic plasticity involve the NMDA and AMPA glutamate receptors. Opening of NMDA channels (which relates to the level of cellular depolarization) leads to a rise in post-synaptic Ca 2+ concentration and this has been linked to long-term potentiation, LTP (as well as to protein kinase activation); strong depolarization of the post-synaptic cell completely ...
Peripheral myelin protein 22 has been shown to interact with myelin protein zero, with the proteins forming complexes in myelin. [14] Transcription factors SOX10 and EGR2 have been found to increase the expression of PMP22 through a super-enhancer upstream of the gene. [ 13 ]
2354 14282 Ensembl ENSG00000125740 ENSMUSG00000003545 UniProt P53539 P13346 RefSeq (mRNA) NM_001114171 NM_006732 NM_008036 NM_001347586 RefSeq (protein) NP_001107643 NP_006723 NP_001334515 NP_032062 Location (UCSC) Chr 19: 45.47 – 45.48 Mb Chr 7: 19.04 – 19.04 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Protein fosB, also known as FosB and G0/G1 switch regulatory protein 3 ...
A large elevation of calcium levels activate protein kinases that ultimately increase the number of postsynaptic AMPA receptors. This increases the sensitivity of the postsynaptic cell to glutamate. As a result, both synapses strengthen.
CREB-TF (CREB, cAMP response element-binding protein) [1] is a cellular transcription factor. It binds to certain DNA sequences called cAMP response elements (CRE), thereby increasing or decreasing the transcription of the genes. [2] CREB was first described in 1987 as a cAMP-responsive transcription factor regulating the somatostatin gene. [3]
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related to: molecular neurobiology if one factor increases the level of protein