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D-dimer (or D dimer) is a dimer that is a fibrin degradation product (FDP), a small protein fragment present in the blood after a blood clot is degraded by fibrinolysis. It is so named because it contains two D fragments of the fibrin protein joined by a cross-link , hence forming a protein dimer .
D-dimer is highly sensitive but not specific (specificity around 50%). In other words, a positive D-dimer is not synonymous with PE, but a negative D-dimer is, with a good degree of certainty, an indication of absence of a PE. [52] A low pretest probability is also valuable in ruling out PE. [53]
However, the sensitivity and specificity of these methods is limited because elevation of these biomarkers can also occur induced in other clinical conditions. The classical coagulation tests such as PT ( prothrombin time ), aPTT ( activated partial thromboplastin time ) or thrombin time are not very sensitive for hyperfibrinolysis, and ...
The purpose of the rule is to select the best method of investigation (e.g. D-dimer testing, CT angiography) for ruling in or ruling out the diagnosis of PE, and to improve the interpretation and accuracy of subsequent testing, based on a Bayesian framework for the probability of the diagnosis.
Sensitivity and specificity values alone may be highly misleading. The 'worst-case' sensitivity or specificity must be calculated in order to avoid reliance on experiments with few results. For example, a particular test may easily show 100% sensitivity if tested against the gold standard four times, but a single additional test against the ...
Huawei Technologies asked a U.S. judge to dismiss much of a federal indictment accusing the Chinese telecommunications company of trying to steal technology secrets from U.S. rivals and misleading ...
An elevated D-dimer in the elderly population has no predictive value for deep venous thrombosis. Signs and symptoms of DVT in general are not sufficiently sensitive or specific to make a diagnosis, being helpful only to help determine the likelihood of a DVT (with the use of a clinical prediction rule such as the Wells score ).
Human remains found in Lebanon Township, Pennsylvania, in 1973 have been identified, officials in the state confirmed. Pennsylvania State Police Sgt. Josh Lacey announced in a press conference on ...
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