Search results
Results from the WOW.Com Content Network
These side effects are serious and some of them are permanent, and many remain a crucial concern for companies and healthcare professionals and substantial efforts are being encouraged to reduce the potential risks for future antipsychotics through more clinical trials and drug development.
Note: "Notable" is to mean side-effects that are particularly unique to the antipsychotic drug in question. For example, clozapine is notorious for its ability to cause agranulocytosis. If data on the propensity of a particular drug to cause a particular AE is unavailable an estimation is substituted based on the pharmacologic profile of the drug.
Common adverse effects of olanzapine, occurring from 1–10%, include: Gynecomastia [8] Extrapyramidal symptoms (EPS) (dose-dependent). Tends to produce less extrapyramidal side effects than typical antipsychotics but more extrapyramidal side effects than sertindole, clozapine and quetiapine. [9] [10]
Neuroleptic malignant syndrome (NMS) is a rare [5] [6] but life-threatening reaction that can occur in response to antipsychotics (neuroleptic) or other drugs that block the effects of dopamine. [1] [7] Symptoms include high fever, confusion, rigid muscles, variable blood pressure, sweating, and fast heart rate. [1]
Almost all the adverse blood reactions occur within the first year of treatment and the majority within the first 18 weeks. [148] After one year of treatment these risks reduce markedly to that seen in other antipsychotic drugs 0.01% or about 1 in 10,000 and the risk of death is markedly lower still. [147]
Extrapyramidal side effects, although potentially serious, are infrequent to rare from olanzapine, [43] but may include tremors and muscle rigidity. Aripiprazole, asenapine, clozapine, quetiapine and olanzapine, in comparison to other antipsychotic drugs, are less frequently associated with hyperprolactinaemia. Although these drugs can cause ...
On average, people receiving quetiapine scored lower (better) than people treated with typical antipsychotic drugs. There was a clear difference between the groups. This finding is based on data of moderate quality. MD 16.20 lower (23.34 to 9.07 lower)* Moderate *The meaning of these findings for day-to-day care is not clear
Campaigners raising awareness about rare adverse reactions to the drugs call this being 'floxed'. Seven years later, John is still suffering from chronic pain and regular muscle spasms.