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In clinical trials, the most common adverse events which occurred at a rate ≥5% and ≥1.5 times placebo included paraesthesia (tingling in fingers/toes), dizziness, altered taste, insomnia, constipation, and dry mouth.
If you need a higher dose after 90 days, your provider can prescribe up to 11.25mg of phentermine and 69mg of topiramate daily for 14 days, followed by 15mg of phentermine and 92mg of topiramate ...
Phentermine was marketed with fenfluramine or dexfenfluramine as a combination appetite suppressant and fat burning agent under the popular name fen-phen. [18] In 1997, after 24 cases of heart valve disease in fen-phen users, fenfluramine and dexfenfluramine were voluntarily taken off the market at the request of the FDA. [19]
Pooled data across five clinical trials showed that the average weight loss after six months on Xenical was 12.4 pounds and after a year of treatment it was 13.4 pounds.
6. Phentermine-topiramate. Dr. Teixeira explains that phentermine and topiramate are two extended release capsules that work together to help with weight loss by decreasing appetite ...
Phentermine is a substituted amphetamine and topiramate has an unknown mechanism of action Approved for weight management (short-term) by the FDA but not the European Medicines Agency [ 54 ] 10% [ 55 ] or 8.25 kilograms (18.2 lb) [ 56 ]
Phentermine-topiramate. Sold under the brand name Qsymia, it is a combination of the drugs phentermine and topiramate, which are taken orally. The medications are used, along with changes in diet ...
The topiramate molecule is a sulfamate modified sugar, more specifically, fructose diacetonide, an unusual chemical structure for a pharmaceutical. Topiramate is quickly absorbed after oral use. It has a half-life of 21 hours and a steady state of the drug is reached in 4 days in patients with normal renal function. [57]