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More than 3,600 cases of debilitating dog health problems caused by the medication were reported between January 2023 and March 2024, the FDA said in the cautionary letter, published Monday.
Samoyeds can be affected by basement membrane disease of the kidneys. It is inherited through the X chromosome and is therefore more severe in affected male dogs. Findings in male dogs include the presence of protein and glucose in the urine and the inability to concentrate urine, and progression to kidney failure by the age of 9 months and death by 16 months. [3]
Deracoxib is a coxib class nonsteroidal anti-inflammatory drug (NSAID). [3] Like other NSAIDs, its effects are caused by inhibition of cyclooxygenase (COX) enzymes. [7] At the doses used to treat dogs, deracoxib causes greater inhibition of COX-2 than of COX-1, [3] but at doses twice those recommended for use in dogs, deracoxib significantly inhibits COX-1 as well.
It can result in chronic kidney failure, hypoalbuminemia, which can cause ascites and peripheral edema, and nephrotic syndrome, which can cause hypertension or hypercoagulability. [156] Familial renal disease is an uncommon cause of kidney failure in young dogs. Most causes are breed-related (familial) and some are inherited.
Dog health is viewed holistically; it encompasses many different aspects, including disease processes, genetics, and nutritional health, for example. Infectious diseases that affect dogs are important not only from a veterinary standpoint, but also because of the risk to public health ; an example of this is rabies .
The dog medication Librela is likely sickening and killing dogs, the FDA warned. Ermolaev Alexandr – stock.adobe.com More than 3,600 cases of Librela harming dogs have been reported to the FDA.
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The disease is specific to the Samoyed, in that the Samoyed is the only breed of dog to show the more rapid progression to kidney failure and death, as well as affecting males to a much more severe degree than females. The Samoyed, however, is not the only breed of dog to suffer from life-threatening renal diseases.