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Finally, note that the benzodiazepine core is a privileged scaffold, which has been used to derive drugs with diverse activity that is not limited to the GABA A modulatory action of the classical benzodiazepines, [60] such as devazepide and tifluadom, however these have not been included in the list below. 2,3-benzodiazepines such as tofisopam ...
In terms of the mechanism of action of benzodiazepines, their similarities are too great to separate them into individual categories such as anxiolytic or hypnotic. For example, a hypnotic administered in low doses produces anxiety-relieving effects, whereas a benzodiazepine marketed as an anti-anxiety drug at higher doses induces sleep. [175]
It should only contain pages that are benzodiazepine compounds or lists of benzodiazepine compounds, as well as subcategories containing those things (themselves set categories). Topics about benzodiazepine compounds in general should be placed in relevant topic categories .
Diazepam, sold under the brand name Valium among others, is a medicine of the benzodiazepine family that acts as an anxiolytic. [14] It is used to treat a range of conditions, including anxiety, seizures, alcohol withdrawal syndrome, muscle spasms, insomnia, and restless legs syndrome. [14]
Benzodiazepines act via micromolar benzodiazepine binding sites as Ca 2+ channel blockers and significantly inhibit depolarization-sensitive calcium uptake in experimentation on rat brain cell components. This has been conjectured as a mechanism for high-dose effects on seizures in the study.
General structure of thienobenzodiazepines. Core is highlighted by black and color.Grey depicts accessory functional groups.. Thienobenzodiazepine is a heterocyclic compound containing a diazepine ring fused to a thiophene ring and a benzene ring.
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Oxazepam is the most slowly absorbed and has the slowest onset of action of all the common benzodiazepines according to one British study. [ 30 ] Oxazepam is an active metabolite formed during the breakdown of diazepam , nordazepam , and certain similar drugs.