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  2. Upshaw–Schulman syndrome - Wikipedia

    https://en.wikipedia.org/wiki/Upshaw–Schulman_syndrome

    Upshaw–Schulman syndrome (USS) is the recessively inherited form of thrombotic thrombocytopenic purpura (TTP), a rare and complex blood coagulation disease. USS is caused by the absence of the ADAMTS13 protease resulting in the persistence of ultra large von Willebrand factor multimers (ULvWF), causing episodes of acute thrombotic microangiopathy with disseminated multiple small vessel ...

  3. Thrombotic thrombocytopenic purpura - Wikipedia

    https://en.wikipedia.org/wiki/Thrombotic...

    Thrombotic thrombocytopenic purpura (TTP) is a blood disorder that results in blood clots forming in small blood vessels throughout the body. [2] This results in a low platelet count , low red blood cells due to their breakdown , and often kidney , heart , and brain dysfunction. [ 1 ]

  4. Inherited thrombotic thrombocytopenic purpura - Wikipedia

    https://en.wikipedia.org/wiki/Inherited_thrombotic...

    Thrombotic thrombocytopenic purpura (TTP) is a life-threatening disorder characterized by thrombocytopenia and microangiopathic hemolytic anemia accompanied by variable neurological dysfunction, kidney failure, and fever. It is caused by severely reduced activity of the von Willebrand factor-cleaving protease ADAMTS13.

  5. Thrombocytopenic purpura - Wikipedia

    https://en.wikipedia.org/wiki/Thrombocytopenic_purpura

    Another form is thrombotic thrombocytopenic purpura. [citation needed] Diagnosis ... This page was last edited on 17 June 2023, at 10:31 (UTC).

  6. Caplacizumab - Wikipedia

    https://en.wikipedia.org/wiki/Caplacizumab

    On 30 August 2018, it was approved in the European Union for the "treatment of adults experiencing an episode of acquired thrombotic thrombocytopenic purpura (aTTP), in conjunction with plasma exchange and immunosuppression". [10] It is an anti-von Willebrand factor humanized immunoglobulin. [11]

  7. Thrombocytopenia - Wikipedia

    https://en.wikipedia.org/wiki/Thrombocytopenia

    Treatment of thrombotic thrombocytopenic purpura (TTP) is a medical emergency, since the associated hemolytic anemia and platelet activation can lead to kidney failure and changes in the level of consciousness. Treatment of TTP was revolutionized in the 1980s with the application of plasmapheresis.

  8. Thrombotic microangiopathy - Wikipedia

    https://en.wikipedia.org/wiki/Thrombotic_microangiopathy

    Thrombotic microangiopathy (TMA) is a pathology that results in thrombosis in capillaries and arterioles, due to an endothelial injury. [1] It may be seen in association with thrombocytopenia, anemia, purpura and kidney failure. The classic TMAs are hemolytic uremic syndrome and thrombotic thrombocytopenic purpura.

  9. Plasmapheresis - Wikipedia

    https://en.wikipedia.org/wiki/Plasmapheresis

    Plasmapheresis of the autologous and exchange types is used to treat a variety of disorders, including those of the immune system, such as Goodpasture's syndrome, [2] Guillain–Barré syndrome, lupus, myasthenia gravis, [3] [4] and thrombotic thrombocytopenic purpura.