Search results
Results from the WOW.Com Content Network
Most paragangliomas are asymptomatic, present as a painless mass, or create symptoms such as hypertension, tachycardia, headache, and palpitations. [3] While all contain neurosecretory granules, only in 1–3% of cases is secretion of hormones such as catecholamines abundant enough to be clinically significant; in that case manifestations often resemble those of pheochromocytomas (intra ...
Mutations in the genes encoding alpha subunits of hypoxia-inducible factors (HIF-alpha) have not previously been identified in any cancer. [4]In the Pacak–Zhuang syndrome, patients have somatic gain of function mutations in the genes encoding for HIF2A, leading to prolonged HIF-2α activity and, thus, an increase in its half-life. [5]
Chromaffin paragangliomas are issued from chromaffin cells, and are known as pheochromocytomas. Adrenal pheochromocytomas are usually benign while extra-adrenal ones are more malignant. [3] They are most of the time in the adrenals, and only rarely outside of the abdomen. They usually secrete hormones and estimates of a familial history vary ...
The new drug is intended for treatment of moderate to severe acute pain in adults. Common Pain Reliever Could Cause Medical Complications In Some People Over 65, Study Suggests
An additional benefit of the DOTA analogues is the ability for treatment with peptide receptor radionuclide therapy, which will be discussed in the treatment section below. [ 98 ] Also, HED-PET has shown to be an accurate tool to diagnose and rule out pheochromocytoma in complex clinical scenarios and to characterise equivocal adrenal tumours.
The US is in the throes an unusually intense and severe flu season, with hospitalization rates topping the levels seen with Covid-19 at some points of the pandemic.
Select a broad spectrum sunscreen (ideally mineral-based) that’s at least 30 SPF, and be sure to reapply it every two hours. However, you shouldn’t rely on sunscreen alone to protect yourself ...
Glomus tumors are modified smooth muscle cells that control the thermoregulatory function of dermal glomus bodies. As stated above, these lesions should not be confused with paragangliomas, which were formerly also called glomus tumors in now-antiquated clinical usage. Glomus tumors do not arise from glomus cells, but paragangliomas do.