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InterPro is a database of protein families, protein domains and functional sites in which identifiable features found in known proteins can be applied to new protein sequences [2] in order to functionally characterise them. [3] [4] The contents of InterPro consist of diagnostic signatures and the proteins that they significantly match.
The small ADP ribosylation factor (Arf) GTP-binding proteins are major regulators of vesicle biogenesis in intracellular traffic. [1] They are the founding members of a growing family that includes Arl (Arf-like), Arp (Arf-related proteins) and the remotely related Sar (Secretion-associated and Ras-related) proteins.
In its MS-DOS (character cell) version, widely considered to be responsible for the explosion of popularity of spreadsheets during the 80s and early 90s. [citation needed] Microsoft Office Excel – for MS Windows and Apple Macintosh. The proprietary spreadsheet leader.
A large group of two component regulator proteins appear to have the same N-terminal structure of 14 tandem repeats.These repeats show homology to members of INTERPRO and INTERPRO indicating that they are likely to form a beta-propeller.
In Microsoft Excel, these functions are defined using Visual Basic for Applications in the supplied Visual Basic editor, and such functions are automatically accessible on the worksheet. Also, programs can be written that pull information from the worksheet, perform some calculations, and report the results back to the worksheet.
The general purpose of the Pfam database is to provide a complete and accurate classification of protein families and domains. [5] Originally, the rationale behind creating the database was to have a semi-automated method of curating information on known protein families to improve the efficiency of annotating genomes. [6]
A C2 domain is a protein structural domain involved in targeting proteins to cell membranes.The typical version (PKC-C2) has a beta-sandwich composed of 8 β-strands that co-ordinates two or three calcium ions, which bind in a cavity formed by the first and final loops of the domain, on the membrane binding face.
In cancerous cells, initiation factors assist in cellular transformation and development of tumors. The survival and growth of cancer is directly related to the modification of initiation factors and is used as a target for pharmaceuticals. Cells need increased energy when cancerous and derive this energy from proteins.