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  2. 4-Hydroxycoumarins - Wikipedia

    en.wikipedia.org/wiki/4-Hydroxycoumarins

    The synthetic drugs in the 4-hydroxycoumarin class are all noted primarily for their use as anticoagulants, though they can have several additional effects.All affect the normal metabolism of vitamin K in the body by inhibiting the enzyme vitamin K epoxide reductase which recycles vitamin K to active form.

  3. Vitamin K antagonist - Wikipedia

    en.wikipedia.org/wiki/Vitamin_K_antagonist

    The term "vitamin K antagonist" is a misnomer, as the drugs do not directly antagonise the action of vitamin K in the pharmacological sense, but rather the recycling of vitamin K. Vitamin K is required for the proper production of certain proteins involved in the blood clotting process.

  4. Warfarin - Wikipedia

    en.wikipedia.org/wiki/Warfarin

    For people who need rapid reversal of warfarin – such as due to serious bleeding – or who need emergency surgery, the effects of warfarin can be reversed with vitamin K, prothrombin complex concentrate (PCC), or fresh frozen plasma (FFP) [13] Generally, four-factor PCC can be given more quickly than FFP, the amount needed is a smaller ...

  5. VKORC1 - Wikipedia

    en.wikipedia.org/wiki/VKORC1

    Warfarin is an anticoagulant that opposes the procoagulant effect of vitamin K by inhibiting the VKORC enzyme. If these patients are prescribed warfarin for another medical purpose, they will require lower doses than usual because the patient is already deficient in VKORC.

  6. Warfarin necrosis - Wikipedia

    en.wikipedia.org/wiki/Warfarin_necrosis

    Warfarin-induced skin necrosis is a condition in which skin and subcutaneous tissue necrosis (tissue death) occurs due to acquired protein C deficiency following treatment with anti-vitamin K anticoagulants (4-hydroxycoumarins, such as warfarin). [1] Warfarin necrosis is a rare but severe complication of treatment with warfarin or related ...

  7. Vitamin K - Wikipedia

    en.wikipedia.org/wiki/Vitamin_K

    Vitamin K is a family of structurally similar, fat-soluble vitamers found in foods and marketed as dietary supplements. [1] The human body requires vitamin K for post-synthesis modification of certain proteins that are required for blood coagulation ("K" from Danish koagulation, for "coagulation") or for controlling binding of calcium in bones and other tissues. [2]

  8. Phytomenadione - Wikipedia

    en.wikipedia.org/wiki/Phytomenadione

    Phytomenadione, also known as vitamin K 1 or phylloquinone, is a vitamin found in food and used as a dietary supplement. [4] [5] It is on the World Health Organization's List of Essential Medicines. [6] It is used to treat certain bleeding disorders, [5] including warfarin overdose, vitamin K deficiency, and obstructive jaundice. [5]

  9. Vitamin K reaction - Wikipedia

    en.wikipedia.org/wiki/Vitamin_K_reaction

    There has been rare reports of oral vitamin K adverse effects. Intravenous vitamin K admission had reports of low blood pressure, shortness of breath, flushing, and other serious allergic reactions. [6] [13] Vitamin K needs to be diluted to an aqueous solution for administration as a it is a fat-soluble vitamin. Reports of hypersensitivity of ...

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