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A-riot-of-rhythms-neuronal-and-glial-circadian-oscillators-in-the-mediobasal-hypothalamus-1756-6606-2-28-S3. Sleep and memory have been closely correlated for over a century. It seemed logical that the rehearsal of learned information during the day, such as in dreams, could be responsible for this consolidation. REM sleep was first studied in ...
A circadian rhythm (/ s ər ˈ k eɪ d i ə n /), or circadian cycle, is a natural oscillation that repeats roughly every 24 hours.Circadian rhythms can refer to any process that originates within an organism (i.e., endogenous) and responds to the environment (is entrained by the environment).
The Rev-Erb proteins are members of the nuclear receptor (NR) superfamily of intracellular transcription factors and key regulatory components of the circadian clock. There are two forms of the receptor, Rev-Erb alpha and Rev-Erb beta, which are each encoded by a separate gene (NR1D1 and NR1D2, respectively). [1] [2]
More specifically, it is a necessary component for the expression of numerous behavioral and physiological circadian rhythms. The dorsomedial hypothalamic nucleus receives information from neurons and humors involved in feeding regulation, body weight and energy consumption, and then passes this information on to brain regions involved in sleep ...
The physiological changes that follow these clocks are known as circadian rhythms. Because the endogenous period of these rhythms are approximately but not exactly 24 hours, these rhythms must be reset by external cues to synchronize with the daily cycles in the environment. [1] This process is called entrainment. One of the most important cues ...
The leading hypothesis of VIP function points to the neurons using VIP to communicate with specific postsynaptic targets to regulate circadian rhythm. [22] The depolarization of the VIP-expressing neurons by light appears to cause the release of VIP and co-transmitters (including GABA ) that can in turn, alter the properties of the next set of ...
Neurons in an intact SCN show coordinated circadian rhythms in electrical activity. [23] Neurons isolated from the SCN have been shown to produce and sustain circadian rhythms in vitro, [24] suggesting that each individual neuron of the SCN can function as an independent circadian oscillator at the cellular level. [25]
The cellular basis of circadian rhythms is supported by the fact that rhythms have been observed in single-celled organisms [1] Beginning in the 1970s, experiments conducted by Ron Konopka and colleagues, in which forward genetic methods were used to induce mutation, revealed that Drosophila melanogaster specimens with altered period ( Per ...
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