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Metformin is considered weight-neutral, meaning it isn’t related to drastic weight gain or loss. However, studies show it can result in modest weight loss in people with diabetes.
Compared with insulin, women with gestational diabetes treated with metformin gain less weight and are less likely to develop pre‐eclampsia during pregnancy. [64] [65] Babies born to women treated with metformin have less visceral fat, and this may make them less prone to insulin resistance in later life. [66]
Metformin is often prescribed alongside a healthy diet and regular exercise to aid weight loss. A healthcare provider can give you guidance on the best changes to make for your lifestyle.
Of the diabetes drugs prescribed off-label for weight loss, metformin is one of the most well-researched. If you have obesity or are struggling to lose weight, talk to a healthcare provider about ...
In addition to diet and exercise, weight loss is an important tool to help with diabetes management. T2D is often associated with obesity and increased abdominal circumference. [ 29 ] Often patients who are at risk of diabetes may be able to reverse their progression to T2D with weight loss as well. [ 29 ]
Metformin is preferred in overweight diabetics and for those gaining weight because taking clozapine for schizophrenia, as it may lead to mild weight loss in comparison to sulfonylureas or insulin. [60] [61] The thiazolidinediones, on the other hand, may cause weight gain, but decrease central obesity. [62]
For women, a drop in estrogen can cause weight gain, particularly in the abdomen (aka menopause belly). For men, low testosterone is linked to an increase in fat mass. Men with obesity are more ...
This is difficult for most patients to achieve in practice, but even smaller losses of 5 kilograms (11 lb) can improve diabetes. While some antidiabetic drugs such as insulin can cause weight gain and worsen diabesity, others such as metformin, SGLT-2 inhibitors, and GLP-1 receptor agonists reduce body weight and hyperglycemia. Therefore, the ...