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Cyproheptadine, sold under the brand name Periactin among others, is a first-generation antihistamine with additional anticholinergic, antiserotonergic, and local anesthetic properties. It was patented in 1959 and came into medical use in 1961. [ 5 ]
The main medical use for pizotifen is for the prevention of migraine and cluster headache.Pizotifen is one of a range of medications used for this purpose, other options include propranolol, topiramate, valproic acid, cyproheptadine and amitriptyline.
Cyproheptadine blocks 5-HT 2A, H1 and is a mild anticholinergic. Methysergide is a 5-HT 2A antagonist and nonselective 5-HT 1 receptor blocker. It causes retroperitoneal fibrosis and mediastinal fibrosis. [citation needed] Quetiapine blocks 5-HT 2A, 5-HT 1A, dopamine receptors D 1 and D 2, histamine receptor H1, and A1 adrenoreceptors.
“Migraine is a genetic neurologic disorder, and, so far, we don’t have treatment to completely stop migraine disease, so it is very important to figure out the best way to use available ...
Chronic migraine is when someone has greater than 15 headache days/month, with [more than] 8 of those days being moderate to severe with associated migraine symptoms, for greater than 3 months." 3.
Living with chronic migraines can be painful and debilitating. Sarah Rathsack shares her symptoms, treatments, and balancing migraine disease with motherhood.
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