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The most notable components of the cell that are targets of cell damage are the DNA and the cell membrane. DNA damage: In human cells, both normal metabolic activities and environmental factors such as ultraviolet light and other radiations can cause DNA damage, resulting in as many as one million individual molecular lesions per cell per day. [5]
Cellular stress response is the wide range of molecular changes that cells undergo in response to environmental stressors, including extremes of temperature, exposure to toxins, and mechanical damage. Cellular stress responses can also be caused by some viral infections. [1]
Stress fractures can be described as small cracks in the bone, or hairline fractures. Stress fractures of the foot are sometimes called "march fractures" because of the injury's prevalence among heavily marching soldiers. [2] Stress fractures most frequently occur in weight-bearing bones of the lower extremities, such as the tibia and fibula ...
Heat-shock proteins can be secreted from immune cells or tumour cells by non-canonical secretion pathway, or leaderless pathway, because they do not have the leader peptide, which navigate proteins into endoplasmic reticulum. The non-canonical secretion can be similar to the one, which occurs for IL1 b, and it is induced by stress conditions. [30]
A bone fracture may be the result of high force impact or stress, or a minimal trauma injury as a result of certain medical conditions that weaken the bones, such as osteoporosis, osteopenia, bone cancer, or osteogenesis imperfecta, where the fracture is then properly termed a pathologic fracture. [3] Most bone fractures require urgent medical ...
Oxidative stress mechanisms in tissue injury. Free radical toxicity induced by xenobiotics and the subsequent detoxification by cellular enzymes (termination).. Oxidative stress reflects an imbalance between the systemic manifestation of reactive oxygen species and a biological system's ability to readily detoxify the reactive intermediates or to repair the resulting damage. [1]
Osteoclasts are prominent in the tissue destruction found in psoriatic arthritis and rheumatological disorders. [3] The human body is in a constant state of bone remodeling. [4] Bone remodeling is a process which maintains bone strength and ion homeostasis by replacing discrete parts of old bone with newly synthesized packets of proteinaceous ...
Fracture strength, also known as breaking strength, is the stress at which a specimen fails via fracture. [2] This is usually determined for a given specimen by a tensile test, which charts the stress–strain curve (see image).