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Extranodal NK/T-cell lymphoma, nasal type (ENKTCL-NT) (also termed angiocentric lymphoma, nasal-type NK lymphoma, NK/T-cell lymphoma, polymorphic/malignant midline reticulosis, [3] and lethal midline granuloma [4]) is a rare type of lymphoma that commonly involves midline areas of the nasal cavity, oral cavity, and/or pharynx [5] At these sites, the disease often takes the form of massive ...
The disease is therefore now regarded as a NK/T cell malignancy, is grouped with other Epstein–Barr virus–associated lymphoproliferative diseases [4] and is classified by the World Health Organization (2017 update) as a manifestation of the well-defined disease, extranodal NK/T-cell lymphoma, nasal type (ENKTCL-NT).
The incidence of T-cell lymphoma are slightly higher in men than in women in all categories of race, [7] with cases increasing in frequency with age for most subtypes. [2] In Asia, T/NK-cell neoplasms are more common as a result of host factors and the higher prevalence of human T-cell leukemia virus-1 (HTLV1) and Epstein–Barr virus (EBV).
Certain lymphomas (extranodal NK/T-cell lymphoma, nasal type and type II enteropathy-associated T-cell lymphoma) can be mimicked by two benign diseases that involve the excessive proliferation of nonmalignant NK cells in the GI tract, natural killer cell enteropathy, a disease wherein NK cell infiltrative lesions occur in the intestine, colon ...
Peripheral T-cell lymphoma refers to a group of T-cell lymphomas that develop away from the thymus [citation needed] or bone marrow. [1] Examples include: [2] Cutaneous T-cell lymphomas; Angioimmunoblastic T-cell lymphoma; Extranodal natural killer/T-cell lymphoma, nasal type; Enteropathy type T-cell lymphoma; Subcutaneous panniculitis-like T ...
IMEP is a chemotherapy regimen that is effective for nasal NK- / T-cell lymphoma. [1] This chemotherapy regimen was also tested in Hodgkin disease as a part of a multidrug alternating scheme COPP / ABV / IMEP. But in that setting it showed no advantage in efficacy and toxicity compared to the use of ABVD or the alternating COPP / ABVD scheme. [2]
Aggressive NK-cell leukemia is a disease with an aggressive, systemic proliferation of natural killer cells (NK cells) and a rapidly declining clinical course. [ 1 ] [ 2 ] [ 3 ] It is also called aggressive NK-cell lymphoma .
SMBA has also been reported to occur in rare cases of EBV positive Hodgkin disease, [28] hydroa vacciniforme, aggressive NK‐cell leukemia (also termed aggressive NK-cell leukemia/lymphoma), and extranodal NK/T-cell lymphoma, nasal type, [29] as well as in EBV negative LPD such as chronic lymphocytic leukemia and mantle cell lymphoma. [28]
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