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4-Chloroaniline is used in the industrial production of pesticides, drugs, and dyestuffs. It is a precursor to the widely used antimicrobial and bacteriocide chlorhexidine and is used in the manufacture of pesticides, including pyraclostrobin , anilofos , monolinuron , and chlorphthalim .
4-Chloro-o-toluidine (4-COT, 4-chloro-2-methylaniline) is the organic compound with the formula CH 3 C 6 H 3 Cl(NH 2). It is a colorless solid. The compound is produced as an intermediate to the pesticide chlordimeform and a precursor to some azo dyes. Production has declined after it was shown to be highly carcinogenic.
By October 1945, DDT was available for public sale in the United States, used both as an agricultural pesticide and as a household insecticide. [9] Although its use was promoted by government and the agricultural industry, US scientists such as FDA pharmacologist Herbert O. Calvery expressed concern over possible hazards associated with DDT as ...
The Pesticide Data Program, [23] a program started by the United States Department of Agriculture is the largest tester of pesticide residues on food sold in the United States. It began in 1991 and tests food for the presence of various pesticides and if they exceed EPA tolerance levels for samples collected close to the point of consumption.
Some organochlorides are considered safe enough for consumption in foods and medicines. For example, peas and broad beans contain the natural chlorinated plant hormone 4-chloroindole-3-acetic acid (4-Cl-IAA); [15] [16] and the sweetener sucralose (Splenda) is widely used in diet products.
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