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Nicotine is an agonist at nicotinic acetylcholine receptor which are present in the central and autonomic nervous systems, and the neuromuscular junction. At low doses nicotine causes stimulatory effects on these receptors, however, higher doses or more sustained exposures can cause inhibitory effects leading to neuromuscular blockade. [4] [30]
[3] The primary symptoms of GTS can be separated into two categories, neurological and respiratory. Those referred to as neurological complaints include headaches, dizziness, nausea, vomiting, chills, weakness, and increased perspiration and salivation. Symptoms that fall into the respiratory category include coughing and trouble breathing. [2]
When trying to quit smoking with vaping a base containing nicotine, symptoms of withdrawal can include irritability, restlessness, poor concentration, anxiety, depression, and hunger. [62] The changes in the brain cause a nicotine user to feel abnormal when not using nicotine. [63]
This is an accepted version of this page This is the latest accepted revision, reviewed on 10 December 2024. Circumstances, mechanisms, and factors of tobacco consumption on human health "Health effects of smoking" and "Dangers of smoking" redirect here. For cannabis, see Effects of cannabis. For smoking crack cocaine, see Crack cocaine § Health issues. "Smoking and health" redirects here ...
Still, if you're looking to quit smoking cigarettes, it's really best to talk to your healthcare provider about your options—and if you're not a smoker, experts advise passing on this trend.
A 2018 Cochrane review found that, in rare cases, nicotine replacement therapy can cause non-ischemic chest pain (i.e., chest pain that is unrelated to a heart attack) and heart palpitations, but does not increase the incidence of serious cardiac adverse events (i.e., myocardial infarction, stroke, and cardiac death) relative to controls. [47]
Good vascular function is important because it means a person’s blood vessels are able to expand and contract so their blood can flow efficiently, delivering oxygen and nutrients to the body and ...
Local irritation can be induced by skin or mucosal nicotine exposure. [172] The nicotine in e-liquid can be hazardous to infants. [173] Even a portion of e-liquid may be lethal to a little child. [174] An excessive amount of nicotine for a child that is capable of being fatal is 0.1–0.2 mg/kg of body weight. [63]