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A low drug load may cause homogeneity problems. A high drug load may pose flow problems or require large capsules if the compound has a low bulk density. By the time phase III clinical trials are reached, the formulation of the drug should have been developed to be close to the preparation that will ultimately be used in the market. A knowledge ...
Lipinski's rule of five, also known as Pfizer's rule of five or simply the rule of five (RO5), is a rule of thumb to evaluate druglikeness or determine if a chemical compound with a certain pharmacological or biological activity has chemical properties and physical properties that would likely make it an orally active drug in humans.
Another use is in the therapeutic drug monitoring of drugs with a narrow therapeutic index. For example, gentamicin is an antibiotic that can be nephrotoxic (kidney damaging) and ototoxic (hearing damaging); measurement of gentamicin through concentrations in a patient's plasma and calculation of the AUC is used to guide the dosage of this drug ...
Specifically, for drug dosing, the patient's length-based dosing zone can be adjusted up one color zone if the child appears overweight. Thus, incorporating a visual estimate of whether the child is overweight provides a simple method to predict actual patient weight that appears to be clinically relevant given the rise in obesity in the U.S ...
Using NHTSA guidelines, the National Registry of Emergency Medical Technicians have developed and implemented certification tests for the NHTSA EMT levels, including the EMT level. [11] As of 2006, 39 US states utilize the NREMT EMT exam as part of the state licensing and/or certification procedure. [12]
Using NHTSA guidelines, the National Registry of Emergency Medical Technicians have developed and implemented certification tests for the NHTSA EMT levels, including the EMT level. [2] As of 2006, 39 US states utilize the NREMT EMT exam as part of the state licensing and/or certification procedure. [3]
The Chinese definition of "bioequivalence" entails having the test drug's geometric mean C max, AUC (0–t), and AUC (0–∞) fall into 80%–125% of the reference drug in both fasting and fed states. The reference drug should be preferably the original brand-name drug, then (if not available) an internationally-recognized generic approved by ...
Routes of administration are usually classified by application location (or exposition). The route or course the active substance takes from application location to the location where it has its target effect is usually rather a matter of pharmacokinetics (concerning the processes of uptake, distribution, and elimination of drugs).
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