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Kidney disease can affect drug elimination, absorption, and distribution in the body, leading to altered serum drug concentrations. This can increase the risk of drug toxicity or suboptimal therapeutic effects. As a result, dosage adjustments are necessary for patients who fail to achieve the desired therapeutic serum drug levels. [27]
Antibiotics that contain beta-lactamase inhibitors (i.e., oral Augmentin or parenteral Unasyn) cover C. canimorsus, as well as other organisms common in bites. [citation needed] Penicillin G is the drug of choice, although some isolates have been found to show resistance. [4]
C. canimorsus and C. cynodegmi are commonly transmitted by dog bites and known to cause sepsis, potentially complicated by thrombotic thrombocytopenic purpura and hemolytic uremic syndrome, in immunocompromised patients. [8] Other complications from infection can include heart attack, kidney failure, gangrene and amputation of limbs. [9]
It is specifically used for otitis media, streptococcal pharyngitis, pneumonia, cellulitis, urinary tract infections, and animal bites. [5] It is taken by mouth or by injection into a vein. [2] Common side effects include diarrhea, vomiting, and allergic reactions. [5] It also increases the risk of yeast infections, headaches, and blood ...
They should also be counseled on the unpleasant side effects including malaise, fatigue, diarrhea, headache, nausea and vomiting. [22] People at high risk for re-exposure due to unprotected intercourse or other behavioral factors should be given PrEP, which would begin immediately after the completion of the nPEP treatment course. Inversely, if ...
The most common side effects of nitrofurantoin are nausea, headache, and flatulence. Less common adverse events (occurring in less than 1% of those taking the drug) include: [9] Gastrointestinal: diarrhea, dyspepsia, abdominal pain, constipation, emesis; Neurologic: dizziness, drowsiness, amblyopia; Respiratory: acute pulmonary hypersensitivity ...
Human bites are the third most frequent type of bite after dog and cat bites. [6] Dog bites are commonplace, with children the most commonly bitten and the face and scalp the most common target. [14] About 4.7 million dog bites are reported annually in the United States. [15] The US estimated annual count of animal bites is 250,000 human bites ...
The drug is administered intravenously every 6 or 8 hr, typically over 3–30 min. It may also be administered by continuous infusion over four hours. Prolonged infusions are thought to maximize the time that serum concentrations are above the minimum inhibitory concentration (MIC) of the bacteria implicated in infection.