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In humans, excess cholesterol in the blood is captured by low-density lipoprotein (LDL) and removed by the liver via endocytosis of the LDL receptor. [4] Recent evidence indicates that the members of the LDL receptor gene family are active in the cell signalling pathways between specialized cells in many, if not all, multicellular organisms. [5 ...
The receptor also recognizes apolipoprotein E (ApoE) which is found in chylomicron remnants and IDL. In humans, the LDL receptor protein is encoded by the LDLR gene on chromosome 19. [6] [7] [8] It belongs to the low density lipoprotein receptor gene family. [9] It is most significantly expressed in bronchial epithelial cells and adrenal gland ...
VLDLR is a member of the low-density-lipoprotein (LDL) receptor family, which is entirely composed of type I transmembrane lipoprotein receptors. The structural differences of the LDL receptor family. This image represents the similarities in structural domains among the members, as well as the extra cysteine repeat present on the VLDL receptor.
The role that is most commonly associated with this evolutionarily ancient gene family is the endocytosis and removal of low-density lipoprotein(LDL), the main carrier of cholesterol in the circulation of humans, by the liver. Indeed, the regulation of cholesterol homeostasis through this mechanism remains the sole known function of the family ...
It is a glycoprotein that binds to the alpha-2-macroglobulin receptor, as well as to other members of the low density lipoprotein receptor family. It acts to inhibit the binding of all known ligands for these receptors, and may prevent receptor aggregation and degradation in the endoplasmic reticulum, thereby acting as a molecular chaperone. [8]
53353 94217 Ensembl ENSG00000168702 ENSMUSG00000049252 UniProt Q9NZR2 Q9JI18 RefSeq (mRNA) NM_018557 NM_053011 RefSeq (protein) NP_061027 n/a Location (UCSC) Chr 2: 140.23 – 142.13 Mb Chr 2: 40.49 – 42.54 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Low-density lipoprotein receptor-related protein 1B is a protein that in humans is encoded by the LRP1B gene. Function LRP1B ...
LRP5 is a transmembrane low-density lipoprotein receptor that shares a similar structure with LRP6. In each protein, about 85% of its 1600-amino-acid length is extracellular. Each has four β-propeller motifs at the amino terminal end that alternate with four epidermal growth factor (EGF)-like repeats. Most extracellular ligands bind to LRP5 ...
LRP6 is a transmembrane low-density lipoprotein receptor that shares a similar structure with LRP5. In each protein, about 85% of its 1600-amino-acid length is extracellular. Each has four YWTD β-propeller motifs at the amino terminal end that alternate with four epidermal growth factor (EGF)-like repeats, followed by three LDLR type A repeats ...