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Leydig cells release a class of hormones called androgens (19-carbon steroids). [8] They secrete testosterone, androstenedione and dehydroepiandrosterone (DHEA), when stimulated by the luteinizing hormone (LH), which is released from the anterior pituitary in response to gonadotropin releasing hormone which in turn is released by the hypothalamus.
The main male sex organs are the penis and the scrotum, which contains the testicles that produce semen and sperm, which, as part of sexual intercourse, fertilize an ovum in the female's body; the fertilized ovum develops into a fetus, which is later born as an infant. The corresponding system in females is the female reproductive system.
Sertoli cells function to nourish the developing sperm cells. They secrete androgen-binding protein, a binding protein which increases the concentration of testosterone. There are two types: convoluted and straight, convoluted toward the lateral side, and straight as the tubule comes medially to form ducts that will exit the testis.
A low testosterone level (hypogonadism) in men may be treated with testosterone administration. Prostate cancer may be treated by removing the major source of testosterone: testicle removal (orchiectomy); or agents which block androgens from accessing their receptor: antiandrogens.
They differ in size according to their position, those in the middle of the gland being larger and longer. The lobules are conical in shape, the base being directed toward the circumference of the organ, the apex toward the mediastinum testis.
The mediastinum testis is a thick yet incomplete septum at the posterior part of the testis formed by the tunica albuginea of testis projecting into the testis at its posterior aspect where the testis is not lined by the serous membrane to allow for the attachment of the epididymis.
Testosterone, which is produced by your testicles, “plays a key role in the development of characteristics like libido, and growth of the penis and testicles,” says Jamin Brahmbhatt, MD, a ...
The Leydig cells are also capable of producing estradiol in addition to their main product testosterone. Estrogen has been found to be essential for spermatogenesis in animals. [ 32 ] [ 33 ] However, a man with estrogen insensitivity syndrome (a defective ERα ) was found produce sperm with a normal sperm count , albeit abnormally low sperm ...
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