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Metformin is more commonly associated with gastrointestinal adverse effects than most other antidiabetic medications. [47] [77] The most serious potential adverse effect of metformin is lactic acidosis; this complication is rare, and seems to be related to impaired liver or kidney function.
5. Metformin. Metformin — a biguanide — is an oral diabetes medication that helps keep blood sugar in check by causing the liver to produce less glucose. It was approved by the FDA in 1994 for ...
Understanding Metformin Side Effects. As noted, timing your metformin dosage is crucial for mitigating the risk — and overall severity — of side effects.
Look out for the common side effects of metformin, which include: Indigestion. Nausea. Vomiting. Diarrhea. Flatulence. Asthenia (feeling weak or lacking energy) Stomach pain. Headache.
Kidney function should be assessed before starting metformin. Phenformin and buformin are more prone to cause acidosis than metformin; therefore they have been practically replaced by it. However, when metformin is combined with other drugs (combination therapy), hypoglycemia and other side effects are possible. [citation needed]
In those with type 2 diabetes, hypoglycemia is less common compared to type 1 diabetics, because medications that treat type 2 diabetes like metformin, glitazones, alpha-glucosidase inhibitors, glucagon-like peptide 1 agonists, and dipeptidyl peptidase IV inhibitors, do not cause hypoglycemia.
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