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The combination has activity against many Gram-positive and Gram-negative bacteria including Pseudomonas aeruginosa. [4] It is used to treat pelvic inflammatory disease, intra-abdominal infection, pneumonia, cellulitis, and sepsis. [4] It is given by injection into a vein. [5]
Piperacillin is a broad-spectrum β-lactam antibiotic of the ureidopenicillin class. [1] The chemical structure of piperacillin and other ureidopenicillins incorporates a polar side chain that enhances penetration into Gram-negative bacteria and reduces susceptibility to cleavage by Gram-negative beta lactamase enzymes.
The main classes of β-lactam antibiotics used to treat gram-negative bacterial infections include (in approximate order of intrinsic resistance to cleavage by β-lactamases) penicillins (especially aminopenicillins and ureidopenicillins), 3rd generation cephalosporins, and carbapenems.
β-Lactam antibiotics are indicated for the prevention and treatment of bacterial infections caused by susceptible organisms. At first, β-lactam antibiotics were mainly active only against gram-positive bacteria, yet the recent development of broad-spectrum β-lactam antibiotics active against various gram-negative organisms has increased their usefulness.
Scientists say they have developed a new type of antibiotic to treat a bacteria that is resistant to most current antibiotics and kills a large percentage of people with an invasive infection.
Gram-negative, Gram-positive, anaerobes. Widely used in veterinary medicine. Rash. Lacks known anemic side-effects. A chloramphenicol analog. May inhibit bacterial protein synthesis by binding to the 50S subunit of the ribosome Tigecycline(Bs) Tigacyl: Slowly Intravenous.
"Without treatment, chronic kidney disease can lead to end-stage kidney failure, which is fatal without dialysis or a kidney transplant." In the United States, more than 1 in 7 ...
Carbapenems exhibit broad spectrum activity against gram-negative bacteria and somewhat narrower activity against gram-positive bacteria. For empiric therapy (treatment of infections prior to identification of the responsible pathogen) they are often combined with a second drug having broader spectrum gram-positive activity. [citation needed]