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The dosage of lactulose for chronic idiopathic constipation is adjusted depending on the constipation severity and desired effect, from a mild stool softener to causing diarrhea. Lactulose is contraindicated in case of galactosemia, as most preparations contain the monosaccharide galactose due to its synthesis process. [14] [15]
Cirrhosis, also known as liver cirrhosis or hepatic cirrhosis, chronic liver failure or chronic hepatic failure and end-stage liver disease, is an acute condition of the liver in which the normal functioning tissue, or parenchyma, is replaced with scar tissue and regenerative nodules as a result of chronic liver disease.
[4] [23] Lactulose does not appear to be more effective than lactitol for treating people with hepatic encephalopathy. [23] Side effects of lactulose and lactitol include the possibility of diarrhea, abdominal bloating, gassiness, and nausea. [23] In acute liver failure, it is unclear whether lactulose is beneficial.
If there is cirrhosis of the liver that has progressed to liver failure, then lactulose may be prescribed for hepatic encephalopathy, especially for Type C encephalopathy with diabetes. [24] Also, "antibiotics such as neomycin , metronidazole , and rifaximin " may be used effectively to treat the encephalopathy by removing nitrogen-producing ...
Lactulose is a carbohydrate that is not absorbed by humans. Lactulose is well known to measure oro-cecal transit time. [11] [1] [4] The mean oro-cecal transit time in normal healthy individuals is 70 to 90 minutes. [12] [13] [8] By 90 minutes, at least 50% of individuals would have delivered the lactulose dose to the colon. Approximately 90 to ...
[12] [13] For example, in vivo testing using lactulose / mannitol consists of ingesting 5 g lactulose and 2 g mannitol followed by determination of urinary concentrations of lactulose and mannitol 5 hours after ingestion. The percentage lactulose excretion and the lactulose mannitol ratio in the urine are calculated and used as a measure of ...
It is a complication of high-dose chemotherapy given before a bone marrow transplant or excessive exposure to hepatotoxic pyrrolizidine alkaloids. It is classically marked by weight gain due to fluid retention , increased liver size , and raised levels of bilirubin in the blood. [ 1 ]
The major criteria include liver disease with portal hypertension; kidney failure; the absence of shock, infection, recent treatment with medications that affect the function of the kidney (nephrotoxins), and fluid losses; the absence of sustained improvement in kidney function despite treatment with 1.5 litres of intravenous normal saline; the ...
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