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The eutomer is the enantiomer having the desired pharmacological activity, [4] e.g., as an active ingredient in a drug. The distomer , on the other hand, is the enantiomer of the eutomer which may have undesired bioactivity or may be bio-inert.
An example of such an enantiomer is the sedative thalidomide, which was sold in a number of countries around the world from 1957 until 1961. It was withdrawn from the market when it was found to cause birth defects. One enantiomer caused the desirable sedative effects, while the other, unavoidably [23] present in equal quantities, caused birth ...
One enantiomer of a drug may have a desired beneficial effect while the other may cause serious and undesired side effects, or sometimes even beneficial but entirely different effects. [1] The desired enantiomer is known as an eutomer while the undesired enantiomer is known as the distomer. [ 2 ]
The (R)-enantiomer has the desired sedative effect while the (S)-enantiomer harbors embryo-toxic and teratogenic effects. Attempting to extract solely R-thalidomide does not remove the risk of birth defects, as it was demonstrated that the "safe" R-thalidomide undergoes an in vivo chiral inversion to the "teratogenic" S-thalidomide.
In chemistry, racemization is a conversion, by heat or by chemical reaction, of an optically active compound into a racemic (optically inactive) form. This creates a 1:1 molar ratio of enantiomers and is referred to as a racemic mixture (i.e. contain equal amount of (+) and (−) forms).
Instead of being able to calmly focus on her chemotherapy treatment, Arete Tsoukalas had to spend hours on the phone arguing with her insurer while receiving infusions in the hospital.
As the l-isomer of glucose, it is the enantiomer of the more common d-glucose. l -Glucose does not occur naturally in living organisms, but can be synthesized in the laboratory. l -Glucose is indistinguishable in taste from d -glucose, [ 1 ] but cannot be used by living organisms as a source of energy because it cannot be phosphorylated by ...
The Year Without a Santa Claus, a Christmas special from Jules Bass and Arthur Rankin, Jr., turns 50 this December. The beloved special was adapted from the book of the same name by Phyllis ...