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  2. Iron overload - Wikipedia

    en.wikipedia.org/wiki/Iron_overload

    Iron overload (also known as haemochromatosis or hemochromatosis) is the abnormal and increased accumulation of total iron in the body, leading to organ damage. [1] The primary mechanism of organ damage is oxidative stress , as elevated intracellular iron levels increase free radical formation via the Fenton reaction .

  3. African iron overload - Wikipedia

    en.wikipedia.org/wiki/African_iron_overload

    African iron overload is an iron overload disorder first observed among people of African descent in Southern Africa and Central Africa. [1] It is now recognized to actually be two disorders with different causes, possibly compounding each other: [2] Dietary iron overload is one contributor to iron overloads observed in African people. Home ...

  4. Transferrin saturation - Wikipedia

    en.wikipedia.org/wiki/Transferrin_saturation

    For instance, a value of 15% means that 15% of iron-binding sites of transferrin are being occupied by iron. The three results are usually reported together. A low transferrin saturation is a common indicator of iron deficiency anemia whereas a high transferrin saturation may indicate iron overload or hemochromatosis.

  5. Too Much—and Too Little—of This Nutrient May Increase Your ...

    www.aol.com/lifestyle/too-much-too-little...

    52 Foods High in Iron, Cleveland Clinic. Hemochromatosis (Iron Overload), Cleveland Clinic. 6 Signs You May Be Iron-Deficient, Cleveland Clinic. Show comments. Advertisement. Advertisement.

  6. Iron metabolism disorder - Wikipedia

    en.wikipedia.org/wiki/Iron_metabolism_disorder

    So, in people with ferroportin proteins that transport iron out of cells without responding to hepcidin's signals to stop, they have a deficiency in the action of hepcidin, if not in hepcidin itself. But the exact mechanisms of most of the various forms of adult hemochromatosis, which make up most of the genetic iron overload disorders, remain ...

  7. Hereditary haemochromatosis - Wikipedia

    en.wikipedia.org/wiki/Hereditary_haemochromatosis

    There are five types of hereditary hemochromatosis: type 1, 2 (2A, 2B), 3, 4 [9] and 5, [10] all caused by mutated genes. Hereditary hemochromatosis type 1 is the most frequent, and uniquely related to the HFE gene. It is most common among those of Northern European ancestry, in particular those of Celtic descent. [11]

  8. Hemosiderosis - Wikipedia

    en.wikipedia.org/wiki/Hemosiderosis

    In hemochromatosis, this entails frequent phlebotomy granulomatosis, immune suppression is required. Limiting blood transfusions and institution of iron chelation therapy when iron overload is detected are important when managing sickle-cell anemia and other chronic hemolytic anemias.

  9. Hepcidin - Wikipedia

    en.wikipedia.org/wiki/Hepcidin

    Hepcidin is a protein that in humans is encoded by the HAMP gene. Hepcidin is a key regulator of the entry of iron into the circulation in mammals. [6]During conditions in which the hepcidin level is abnormally high, such as inflammation, serum iron falls due to iron trapping within macrophages and liver cells and decreased gut iron absorption.