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Mexazolam [1] (marketed under the trade names Melex and Sedoxil) [2] is a drug which is a benzodiazepine derivative. [3] Mexazolam has been trialed for anxiety and was found to be effective in alleviating anxiety at one week follow-up.
It is mainly an anti-anxiety agent with similar side effects to diazepam. In addition to being used to treat anxiety or panic states, bromazepam may be used as a premedicant prior to minor surgery. Bromazepam typically comes in doses of 3 mg and 6 mg tablets. [4] It was patented in 1961 by Roche and approved for medical use in 1974. [5]
Clobazam, sold under the brand names Frisium, Onfi and others, is a benzodiazepine class medication that was patented in 1968. [3] Clobazam was first synthesized in 1966 and first published in 1969.
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Guanfacine is also used off-label to treat tic disorders, anxiety disorders such as generalized anxiety disorder, and PTSD. [ 24 ] [ 15 ] Guanfacine and other α 2A -adrenergic receptor agonists have anxiolytic -like action, [ 25 ] thereby reducing the emotional responses of the amygdala , and strengthening prefrontal cortical regulation of ...
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Opipramol is said to have a biphasic action, with prompt initial improvement of tension, anxiety, and insomnia followed by improved mood later. [3] Hence, it is an anxiolytic with an antidepressant component. [3] After sub-chronic treatment with opipramol, σ 2 receptors are significantly downregulated but σ 1 receptors are not. [3]
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