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Flaccid paralysis resulting from cholinergic crisis can be distinguished from myasthenia gravis by the use of the drug edrophonium (Tensilon), as it only worsens the paralysis caused by cholinergic crisis but strengthens the muscle response in the case of myasthenia gravis. (Edrophonium is a cholinesterase inhibitor, hence increases the ...
A toxidrome (a portmanteau of toxic and syndrome, coined in 1970 by Mofenson and Greensher [2]) is a syndrome caused by a dangerous level of toxins in the body. It is often the consequence of a drug overdose.
Cholinergic agents are compounds which mimic the action of acetylcholine and/or butyrylcholine. [1] In general, the word " choline " describes the various quaternary ammonium salts containing the N , N , N -trimethylethanolammonium cation .
For people affected by cholinergic syndrome, atropine sulfate combined with an oxime is used to combat the effects of the acute OP poisoning. Diazepam is sometimes also administered if convulsions or muscle fasciculations begin. [16] The intermediate syndrome (IMS) appears in the interval between the end of the cholinergic crisis and the onset ...
Nerve agents attack the nervous system.All such agents function the same way resulting in cholinergic crisis: they inhibit the enzyme acetylcholinesterase, which is responsible for the breakdown of acetylcholine (ACh) in the synapses between nerves that control whether muscle tissues are to relax or contract.
Cholinergic crisis. Actions on the neuromuscular junction may result in prolonged muscle contraction. [21] The effects of neostigmine on postoperative nausea and vomiting are controversial and there is not a clear linkage in clinical practice, however, there is good evidence to support the reduction in risk when anticholinergic agents are ...
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A parasympathomimetic drug, sometimes called a cholinomimetic drug [1] or cholinergic receptor stimulating agent, [2] is a substance that stimulates the parasympathetic nervous system (PSNS). [ 3 ] [ 2 ] These chemicals are also called cholinergic drugs because acetylcholine (ACh) is the neurotransmitter used by the PSNS.