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If ipratropium is inhaled, side effects resembling those of other anticholinergics are minimal. However, dry mouth and sedation have been reported. Also, effects such as skin flushing, tachycardia, acute angle-closure glaucoma, nausea, palpitations, and headache have been observed. Inhaled ipratropium does not decrease mucociliary clearance. [21]
In the process, metabolites, or byproducts, of the drug are produced, which can linger in our blood, urine (and even in our hair) for long after the initial effects of the drug are felt.
These medications usually take effect within 20 minutes or less, and can last from four to six hours. These inhaled medications are best for treating sudden and severe or new asthma symptoms. Taken 15 to 20 minutes ahead of time, these medications can also prevent asthma symptoms triggered by exercise or exposure to cold air.
Symptoms can start within an hour of exposure, and can last for several months. [1] [3] [5] Early symptoms are usually nausea, vomiting and loss of appetite. [1] In the following hours or weeks, initial symptoms may appear to improve, before the development of additional symptoms, after which either recovery or death follow. [1]
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When combined with inhaled steroids, β adrenoceptor agonists can improve symptoms. [ 1 ] [ 2 ] In children this benefit is uncertain and they may be potentially harmful. [ 2 ] They should not be used without an accompanying steroid due to an increased risk of severe symptoms, including exacerbation in both children and adults. [ 3 ]
How long the symptoms last depends on the severity of the case. With more mild cases (meaning that symptoms are similar to the common cold or flu), people tend to get better on their own after a ...
The most common symptoms of overdose include central nervous system (CNS) depression, impaired balance, ataxia, and slurred speech. Severe symptoms include coma and respiratory depression. Supportive care is the mainstay of treatment of benzodiazepine overdose. There is an antidote, flumazenil, but its use is controversial. [2]
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