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In her final year at UCSD, she worked in the laboratory of Russell F. Doolittle studying fibrinogen, a blood clotting factor. [1] She became an author on several papers through her undergraduate work, specifically characterizing the amino acid sequences of the alpha chain of fibrinogen. [3] She graduated in 1976 with a degree in chemistry. [1]
2006 Young Investigator Award from the International Fibrinogen Society [2] 2006 Presidential Early Career Award for Scientists and Engineers (PECASE) [2] 2007 Dana Award in Brain and Immunoimaging [2] 2008 John J Abel Award in Pharmacology (4th female in 60 years to win this award). [18] 2009 EUREKA Award from the National Institutes of Health [2]
Doolittle notably co-developed the hydropathy index, and was instrumental in determining the structure of fibrinogen.Dootlittle was a member of the National Academy of Sciences from 1984, [5] was a Guggenheim Fellow and was a co-recipient of the Paul Ehrlich Prize.
Fibrinogen is made and secreted into the blood primarily by liver hepatocyte cells. Endothelium cells are also reported to make small amounts of fibrinogen, but this fibrinogen has not been fully characterized; blood platelets and their precursors, bone marrow megakaryocytes, while once thought to make fibrinogen, are now known to take up and store but not make the glycoprotein.
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Scientific career: Fields: ... Agnes Henschen, and she used Edman's method to sequence fibrinogen. In 1977, Edman died of a brain tumor after a short coma. References
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