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There are increased side effects with sublingual or oral misoprostol, compared to a low dose (400 μg) vaginal misoprostol. However, low dose vaginal misoprostol was linked with low complete abortion rate. [42] The study concluded that sublingually administered misoprostol dosed at 600 μg or 400 μg had greater instances of fever and diarrhea ...
For pregnancies after 9 weeks, two doses of misoprostol (the second drug) makes the treatment more effective. [21] From 10 to 11 weeks of pregnancy, the National Abortion Federation suggests second dose of misoprostol (800 micrograms) four hours after the first dose. [22] After the patient takes mifepristone, they must also administer the ...
Vaginally administered misoprostol had improved outcomes of inducing labor within twenty four hours compared to oxytocin, but was associated with uterine hyperstimulation. [15] Misoprostol is an agonist of EP1 and EP3 receptors, and can cause a greater stimulation at lower concentrations.
Early medical abortion regimens using mifepristone, followed 24–48 hours later by buccal or vaginal misoprostol are 98% effective up to 9 weeks gestational age; from 9 to 10 weeks efficacy decreases modestly to 94%. [64] [68] If medical abortion fails, surgical abortion must be used to complete the procedure. [69]
A gonadotropin-releasing hormone agonist (GnRH agonist) is a type of medication which affects gonadotropins and sex hormones. [1] They are used for a variety of indications including in fertility medicine and to lower sex hormone levels in the treatment of hormone-sensitive cancers such as prostate cancer and breast cancer, certain gynecological disorders like heavy periods and endometriosis ...
This treatment avoids the possible side effects and complications of medications and surgery, [129] but increases the risk of mild bleeding, the need for unplanned surgical treatment, and incomplete miscarriage. Medical treatment usually consists of using misoprostol (a prostaglandin) alone or in combination with mifepristone pre-treatment. [130]
Three doctors told NBC News that if she was given misoprostol, depending on the dose, it could have played a role. One of its most dangerous side effects is to potentially reduce a baby’s blood ...
For first-trimester abortion, it is dissolved in the cheek or under the tongue; for later abortions, it can also be given as a vaginal suppository. Misoprostol may also be used to ripen the cervix in preparation for surgical abortion. [20] Misoprostol is given orally for the treatment of ulcers.
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