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Clomipramine is mostly excreted in urine (60%) and feces (32%). [18] Although the normal maximum-recommended total daily dosage of clomipramine is 250 milligrams, treatment-resistant cases of depression [156] and obsessive-compulsive disorder may require corresponding doses within the range of 255 to 300 milligrams.
Tricyclic antidepressants (TCAs) are a class of medications that are used primarily as antidepressants. TCAs were discovered in the early 1950s and were marketed later in the decade. [1] They are named after their chemical structure, which contains three rings of atoms. Tetracyclic antidepressants (TeCAs), which contain four rings of atoms, are ...
Lunesta (eszopiclone) – a non-benzodiazepine hypnotic. Luvox (fluvoxamine) – an antidepressant of the SSRI class. Loxitane (loxapine) – an antipsychotic used in the treatment of mood disorders and schizophrenia. Lyrica (pregabalin) – treats nerve and muscle pain, including fibromyalgia. It can also treat seizures.
Duloxetine is one of the most commonly used prescription medications in the U.S. Patients with depression are usually prescribed 40 to 60 milligrams per day, with a potential increase of up to 120 ...
Maprotiline. Maprotiline, sold under the brand name Ludiomil among others, is a tetracyclic antidepressant (TeCA) that is used in the treatment of depression. [5] It may alternatively be classified as a tricyclic antidepressant (TCA), specifically a secondary amine. [5] In terms of its chemistry and pharmacology, maprotiline is closely related ...
A loading dose is most useful for drugs that are eliminated from the body relatively slowly, i.e. have a long systemic half-life. Such drugs need only a low maintenance dose in order to keep the amount of the drug in the body at the appropriate therapeutic level, but this also means that, without an initial higher dose, it would take a long ...
Tranylcypromine, sold under the brand name Parnate among others, [1] is a monoamine oxidase inhibitor (MAOI). [4][7] More specifically, tranylcypromine acts as nonselective and irreversible inhibitor of the enzyme monoamine oxidase (MAO). [4][7] It is used as an antidepressant and anxiolytic agent in the clinical treatment of mood and anxiety ...
Most antidepressants, including SNRIs, are safe and effective in the geriatric population. Decisions are often based on co-morbid conditions, drug interactions, and patient tolerance. Due to differences in body composition and metabolism, starting doses are often half that of the recommended dose for younger adults. [92]
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