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VMA is found in the urine, along with other catecholamine metabolites, including homovanillic acid (HVA), metanephrine, and normetanephrine.In timed urine tests the quantity excreted (usually per 24 hours) is assessed along with creatinine clearance, and the quantity of cortisols, catecholamines, and metanephrines excreted is also measured.
Values greater than 25 mg per 24 hours (higher if the patient has malabsorption) are strong evidence for carcinoid. The normal range is 2 to 6 mg per 24 hours. [4] Low levels of 5-HIAA in the cerebrospinal fluid have been associated with aggressive behavior and suicide by violent means, correlating with diminished serotonin levels. [5]
1-mg overnight dexamethasone suppression test; 24-hour urinary specimen for measurement of fractionated metanephrines and catecholamines; Blood plasma aldosterone concentration and plasma renin activity, if hypertension is present
Twenty-four hour urinary metanephrines are an acceptable alternative if the plasma test is unavailable. [71] Other additional biomarkers can be helpful to aid in the diagnosis of pheochromocytoma as well, most notable is Chromogranin A .
Urinary specific gravity: 1.003 [1] [2] 1.030 [1] [2] g/mL Urobilinogen: 0.2 [2] 1.0 [2] Ehrlich units or mg/dL Free catecholamines, dopamine: 90 [3] 420 [3] μg/d Red blood cells (RBCs) 0 [4] [2] 2 [2] - 3 [4] per High Power Field (HPF) RBC casts: n/a 0 / negative [2] White blood cells (WBCs) 0 [2] 2 [2] pH: 5 [2] 7 [2] (unitless) Protein: 0 ...
Example of a container used for collecting 24-hour urine samples. This particular container is free of trace metals to allow for accurate measurement of these substances in urine. The techniques used to collect urine specimens vary based on the desired test. A random urine, meaning a specimen that is collected at any time, can be used for many ...
1-mg overnight dexamethasone suppression test; 24-hour urinary specimen for measurement of fractionated metanephrines and catecholamines; Blood plasma aldosterone concentration and plasma renin activity, if hypertension is present; On CT scan, benign adenomas typically are of low radiodensity (due to fat content).
Urinalysis, a portmanteau of the words urine and analysis, [1] is a panel of medical tests that includes physical (macroscopic) examination of the urine, chemical evaluation using urine test strips, and microscopic examination.
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