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Acute promyelocytic leukemia is characterized by a chromosomal translocation involving the retinoic acid receptor alpha (RARA) gene on chromosome 17. [3] In 95% of cases of APL, the RARA gene on chromosome 17 is involved in a reciprocal translocation with the promyelocytic leukemia gene (PML) on chromosome 15, a translocation denoted as t(15;17)(q22;q21). [3]
The signs and symptoms of colorectal cancer depend on the location of the tumor in the bowel, and whether it has spread elsewhere in the body ().The classic warning signs include: worsening constipation, blood in the stool, decrease in stool caliber (thickness), loss of appetite, loss of weight, and nausea or vomiting in someone over 50 years old. [15]
A prospective study found that increased hepatocellular cancer risk is associated with higher levels of major circulating bile acids that were measured in people several years prior to tumor diagnosis. [104] In another study using a mouse model, it was found that dysregulated hepatic bile acids collaboratively promote liver carcinogenesis. [105]
By 2050, global life expectancy, which was 72.6 years in 2019, is expected to increase by approximately five years. [166] Maintaining good nutritional status and adequate nutrient intake is essential for health, quality of life, and overall well-being in older age, and it plays a crucial role in healthy aging as defined by the WHO.
2660 17700 Ensembl ENSG00000138379 ENSMUSG00000026100 UniProt O14793 O08689 RefSeq (mRNA) NM_005259 NM_010834 RefSeq (protein) NP_005250 NP_034964 Location (UCSC) Chr 2: 190.06 – 190.06 Mb Chr 1: 53.1 – 53.11 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse In humans, the MSTN gene is located on the long (q) arm of chromosome 2 at position 32.2. Myostatin (also known as growth ...