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In 1927, Sakel, who had recently qualified as a medical doctor in Vienna and was working in a psychiatric clinic in Berlin, began to use low (sub-coma) doses of insulin to treat drug addicts and psychopaths, and when one of the patients experienced improved mental clarity after having slipped into an accidental coma, Sakel reasoned the treatment might work for mentally ill patients. [3]
People with type 1 diabetes mellitus who must take insulin in full replacement doses are most vulnerable to episodes of hypoglycemia (low blood glucose levels). This can occur if a person takes too much insulin or diabetic medication, does strenuous exercise without eating additional food, misses meals, consumes too much alcohol, or consumes alcohol without food. [5]
The term "shock therapy" [3] gained widespread attention following Sakel's 1933 publication on the efficacy of insulin therapy in schizophrenia treatment. This method, revolutionary at the time for addressing psychosis, entailed insulin injections to induce convulsions and comas.
See also: Hypoglycemia; insulin shock. Insulin receptors Protein complexes on the surface of a cell that allows the cell to join or bind with insulin that is in the blood. When the vrll membrane receptor and insulin bind, the cell takes up glucose (sugar) from the blood and can use it for energy. Insulin resistance
Defibrillation, electric shock to restore heart rhythm; Electroconvulsive therapy or shock treatment, psychiatric treatment; Hydrostatic shock, from ballistic impact; Insulin shock or diabetic hypoglycemia, from too much insulin Insulin shock therapy, purposely induced insulin shock, obsolete therapy
When individuals take insulin without needing it, to purposefully induce hypoglycemia, this is referred to as surreptitious insulin use or factitious hypoglycemia. [ 3 ] [ 2 ] [ 24 ] Some people may use insulin to induce weight loss, whereas for others this may be due to malingering or factitious disorder , which is a psychiatric disorder . [ 24 ]
Michaels, now 61, was diagnosed with type 1 diabetes when he was just 6 years old, meaning that he had to be extra-careful Bret Michaels Recalls ‘Life-Threateningly Tough’ Early Days of Poison ...
Diabetic hypoglycemia can occur in any person with diabetes who takes any medicine to lower their blood glucose, but severe hypoglycemia occurs most often in people with type 1 diabetes who must take insulin for survival. In type 1 diabetes, iatrogenic hypoglycemia is more appropriately viewed as the result of the interplay of insulin excess ...