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Trimethylsilyl trifluoromethanesulfonate has a variety of other specialized uses. It has been used to install tert-alkyl groups on phosphine (R = alkyl): [6] PH 3 + R 3 C–OAc + Me 3 SiOTf → [(R 3 C) 2 PH 2]OTf. Deprotection of Boc-protected amines can be achieved using trimethylsilyl trifluoromethanesulfonate and triethylamine or 2,6 ...
The group is unaffected by treatment with 80% acetic acid, which catalyses the deprotection of O-tetrapyranyl, O-trityl and O-tert-butyldimethylsilyl ethers. It is also unaffected by 50% trifluoroacetic acid (TFA) , and survives the harsh acidic conditions used to install and remove isopropylidene or benzylidene acetals.
In organic chemistry, triflate (systematic name: trifluoromethanesulfonate), is a functional group with the formula R−OSO 2 CF 3 and structure R−O−S(=O) 2 −CF 3. The triflate group is often represented by −OTf, as opposed to −Tf, which is the triflyl group, R−SO 2 CF 3. For example, n-butyl triflate can be written as CH 3 CH 2 CH ...
TBS (tert-butyldimethylsilyl) [2] tert-Butyldimethylsilyl triflate, lutidine, 4-(dimethylamino)pyridine, and dichloromethane Camphorsulfonic acid: Protection of the tertiary hydroxyl group in 1.8 was necessary to allow selective protection of other hydroxyl groups on the C ring. TBS (tert-butyldimethylsilyl) [3] tert-Butyldimethylsilyl chloride ...
Related: Cancer-Causing 'Forever Chemicals' Found in Many Kinds of Contact Lenses, Study Finds The issue, the statement says, comes from a synthetic polymer called fluoroelastomer, which is used ...
The general structure is R 1 R 2 R 3 Si−O−R 4 where R 4 is an alkyl group or an aryl group. Silyl ethers are usually used as protecting groups for alcohols in organic synthesis . Since R 1 R 2 R 3 can be combinations of differing groups which can be varied in order to provide a number of silyl ethers, this group of chemical compounds ...
Wrist-worn devices can predict imminent inflammatory and symptomatic inflammatory bowel disease flare-ups as far in advance as 7 weeks, a study suggests.
tert-Butyldimethylsilyl (TBDMS or TBS) — Cleaved with acetic acid in tetrahydrofuran/water, [12] Pyridinium tosylate in methanol, [13] trifluoroacetic acid in water, [14] hydrofluoric acid in acetonitrile, [15] pyridinium fluoride in tetrahydrofuran, [16] tetrabutylammonium fluoride in THF. [17]