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The Cancer Slope Factor is used to derive the Risk Specific Dose (RSD)(mg/kg-day) for direct-acting carcinogenic agents, those that cause chemical changes in DNA. It is also the default choice for carcinogens when there are insufficient data to demonstrate that the mode of action of the chemical is nonlinear.
Insulin glargine sold under the brand name Lantus among others is a long-acting modified form of medical insulin, used in the management of type 1 and type 2 diabetes. [7] It is injected just under the skin . [ 7 ]
Environmentally relevant doses of endosulfan equal to the EPA's safe dose of 0.006 mg/kg/day have been found to affect gene expression in female rats similarly to the effects of estrogen. [49] It is not known whether endosulfan is a human teratogen (an agent that causes birth defects), though it has significant teratogenic effects in laboratory ...
A reference dose is the United States Environmental Protection Agency's maximum acceptable oral dose of a toxic substance, "below which no adverse noncancer health effects should result from a lifetime of exposure". Reference doses have been most commonly determined for pesticides. The EPA defines an oral reference dose (abbreviated RfD) as:
Bukowinski said that consortiums, such as the Children’s Oncology Group, comprised of 200 pediatric cancer institutes, help advance pediatric cancer research. “It allows us to share ...
Convenient dosing; Increase the risk of heart failure; Cause an average of 2–5 kg weight gain; Are associated with a higher risk of edema, anemia and bone fractures; Can increase low-density lipoprotein; Rosiglitazone has been linked to increased triglycerides and an increased risk of a heart attack
May Increase Your Risk of Cancer. ... Two five-ounce glasses of wine per day fall within the health guidelines for men. However, women should limit their intake to one glass of wine per day.
Acceptable daily intake or ADI is a measure of the amount of a specific substance (originally applied for a food additive, later also for a residue of a veterinary drug or pesticide) in food or drinking water that can be ingested (orally) daily over a lifetime without an appreciable health risk. [1]