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Capsule endoscopy is considered to be a very safe method for gastrointestinal tract examination. The capsule is usually excreted with a patient's feces within 24–48 hours after ingestion. There has been a single report of retention of the capsule lasting almost four and a half years although the patient was asymptomatic.
In November 2004, US FDA clears PillCam(R) ESO for the esophagus In May 2006, US FDA clears Agile Patency System [7] In October 2006, PillCam COLON was cleared for marketing in the European Union (CE Mark) [8] In December 2008, Given Imaging acquired Bravo pH Monitoring System(R) In May 2009, 1 millionth PillCam capsule was sold [9]
Capsule contents may be released by melting the wall, or dissolving it under particular conditions, as in the case of an enteric drug coating. [7] In other systems, the wall is broken by solvent action, enzyme attack, chemical reaction, hydrolysis, or slow disintegration. Microencapsulation can be used to slow the release of a drug into the body.
Capsule fill weight is a critical attribute in encapsulation and various real-time fill weight monitoring techniques such as near-infrared spectroscopy (NIR) and vibrational spectroscopy are used, as well as in-line weight checks, to ensure product quality.
For this reason, producers of drugs such as OTC analgesics wanting to emphasize the strength of their product developed the "caplet", a portmanteau [6] of capsule-shaped tablet, [7] [8] in order to tie this positive association to more efficiently produced tablet pills as well as being an easier-to-swallow shape than the usual disk-shaped tablet.
The dies contain recesses in the desired size and shape, which cut out the ribbons into a two-dimensional shape, and form a seal around the outside. At the same time a pump delivers a precise dose of fill material through a nozzle incorporated into a filling wedge whose tip sits between the two ribbons in between two die pockets at the point of ...
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A two-dimensional orthographic projection at the left with a three-dimensional one at the right depicting a capsule. A capsule (from Latin capsula, "small box or chest"), or stadium of revolution, is a basic three-dimensional geometric shape consisting of a cylinder with hemispherical ends. [1] Another name for this shape is spherocylinder. [2 ...
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