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Gepants have been suggested to have less pain relief at 2 hours compared to triptans. Similar to ditans, they offer another therapy option that does not include vasoconstriction, thus may be suitable for those with cardiovascular risk factors. [7] They are well tolerated with fewer adverse effects compared to triptans . [7]
Triptan structures were designed from the structure of 5-HT to attain affinity to 5-HT receptors, hence the identical indole structure. The hydroxyl group (-OH) on the hexane of the indole core and the alkyl-amine side chain on position C 3 on 5-HT have been replaced with other compounds, such as sulfonamides or azol-ring structured derivatives ...
Rescue treatment involves acute symptomatic control with medication. [4] Recommendations for rescue therapy of migraine include: (1) migraine-specific agents such as triptans, CGRP antagonists, or ditans for patients with severe headaches or for headaches that respond poorly to analgesics, (2) non-oral (typically nasal or injection) route of administration for patients with vomiting, (3) avoid ...
Triptans have a wide variety of pharmacokinetic properties. Bioavailability is between 14% and 70%, biological half-life (T 1/2 ) is between 2 and 26 hours. Their good ability to cross the blood–brain barrier and the rather long half life of some triptans may result in lower frequencies of migraine recurrence.
Florida State Fair in 2013. In 1904, the South Florida Fair Association was formed and plans for a new exhibition were proposed. The fair was founded as the South Florida Fair in downtown Tampa and renamed the Mid-Winter Festival a few years later. The name finally changed to the present Florida State Fair in 1915. [7]
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The Florida State Fairgrounds in East Lake-Orient Park, Florida, hosts the annual Florida State Fair and various other events. [1] Covering 355 acres (1.44 km 2 ), it features a variety of buildings.
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