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GNC Holdings, LLC (an initialism of General Nutrition Centers) is an American multinational retail and nutritional manufacturing company based in Pittsburgh, Pennsylvania. [5] [6] It specializes in health and nutrition related products, including vitamins, supplements, minerals, herbs, sports nutrition, diet, and energy products.
Single doses of psilocybin of 3 to 30 mg have been found to dose-dependently occupy the serotonin 5-HT 2A receptor in humans as assessed by imaging studies. [10] The EC 50 Tooltip half-maximal effective concentration for occupancy of the serotonin 5-HT 2A receptor by psilocin in terms of circulating levels has been found to be 1.97 ng/mL.
Most commonly, gummy supplements are made from gelatin, cornstarch, water and sugar, along with flavorings. [7]Although gummy vitamins are the most popular type of gummy supplements, they may also be derived from herbal supplements, containing extracts from plants like ashwagandha [8] and cannabis (e.g., CBD), [9] as well as the algae-derived astaxanthin.
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The Austrian Ministry of Health announced on December 18, 2008, that Spice would be controlled under Paragraph 78 of their drug-law on the grounds that it contains an active substance that affects the functions of the body, and the legality of JWH-018 is under review. [127] [128] [129]
In terms of psilocybin dosing, subthreshold or microdoses are <2.5 mg, low doses are 5 to 10 mg, the intermediate or "good effect" dose is 20 mg, and high or ego-dissolution doses are 30 to 40 mg. [59] [48] A 20 mg dose of psilocybin is equivalent to about 100 μg LSD or about 500 mg mescaline. [59]
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