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  2. Gilbert's syndrome - Wikipedia

    en.wikipedia.org/wiki/Gilbert's_syndrome

    Cholestasis can be excluded by normal levels of bile acids in plasma, the absence of lactate dehydrogenase, low levels of conjugated bilirubin, and ultrasound scan of the bile ducts. Vitamin B12 deficiency - elevated bilirubin levels (and MCV counts above 90–92) can be associated with a vitamin B12 deficiency.

  3. Liver function tests - Wikipedia

    en.wikipedia.org/wiki/Liver_function_tests

    Lactate dehydrogenase (LDH) is found in many body tissues, including the liver. Elevated levels of LDH may indicate liver damage. [ 18 ] LDH isotype-1 (or cardiac) is used for estimating damage to cardiac tissue, although troponin and creatine kinase tests are preferred.

  4. Lactate dehydrogenase - Wikipedia

    en.wikipedia.org/wiki/Lactate_dehydrogenase

    Lactate dehydrogenase (LDH or LD) is an enzyme found in nearly all living cells. LDH catalyzes the conversion of pyruvate to lactate and back, as it converts NAD + to NADH and back. A dehydrogenase is an enzyme that transfers a hydride from one molecule to another. LDH exists in four distinct enzyme classes.

  5. Lactic acidosis - Wikipedia

    en.wikipedia.org/wiki/Lactic_acidosis

    Lactic acidosis refers to the process leading to the production of lactate by anaerobic metabolism. It increases hydrogen ion concentration tending to the state of acidemia or low pH. The result can be detected with high levels of lactate and low levels of bicarbonate. This is usually considered the result of illness but also results from ...

  6. Cardiac marker - Wikipedia

    en.wikipedia.org/wiki/Cardiac_marker

    Lactate dehydrogenase (LDH) LDH is not as specific as troponin. 72 hours Lactate dehydrogenase catalyses the conversion of pyruvate to lactate. LDH-1 isozyme is normally found in the heart muscle and LDH-2 is found predominantly in blood serum. A high LDH-1 level to LDH-2 suggest MI. LDH levels are also high in tissue breakdown or hemolysis.

  7. Multiple myeloma - Wikipedia

    en.wikipedia.org/wiki/Multiple_myeloma

    The revised ISS (R-ISS) was published in 2015 and incorporates cytogenetics and lactate dehydrogenase (LDH). [81]: 1730–1 [82] [83]: 732–3 Stage I: β 2 microglobulin (β2M) < 3.5 mg/L, albumin ≥ 3.5 g/dL, normal cytogenetics, no elevated LDH; Stage II: Not classified under Stage I or Stage III

  8. Hemolytic jaundice - Wikipedia

    en.wikipedia.org/wiki/Hemolytic_jaundice

    This disease is marked by increased extravascular hemolysis, with laboratory findings including increased lactate dehydrogenase and decreased or absent haptoglobin in both warm and cold AIHA, and positive Coombs test. [5] Clinically, jaundice or dark urine present in approximately one-third of the cases, and most of the symptoms are related to ...

  9. Pyruvate carboxylase deficiency - Wikipedia

    en.wikipedia.org/wiki/Pyruvate_carboxylase...

    Pyruvate carboxylase deficiency type B has life-threatening signs and symptoms that become apparent shortly after birth. This form of the condition has been reported mostly in Europe, particularly France. Affected infants have severe lactic acidosis, a build-up of ammonia in the blood (hyperammonemia), and liver failure.