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A transcriptional activator is a protein (transcription factor) that increases transcription of a gene or set of genes. [1] Activators are considered to have positive control over gene expression, as they function to promote gene transcription and, in some cases, are required for the transcription of genes to occur.
Additionally, adding methyl groups to the SHP-1 gene (which reduces the amount of SHP-1 produced) has been linked to lymphoma (a type of blood cancer) . [43] However, SHP-1 may also promote JAK-STAT signalling. A study in 1997 found that SHP-1 potentially allows higher amounts of STAT activation, as opposed to reducing STAT activity. [44]
54426 Ensembl ENSG00000109758 ENSMUSG00000029102 UniProt Q04756 Q9R098 RefSeq (mRNA) NM_001297439 NM_001528 NM_019447 RefSeq (protein) NP_001284368 NP_001519 NP_062320 Location (UCSC) Chr 4: 3.44 – 3.45 Mb Chr 5: 35.2 – 35.21 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Hepatocyte growth factor activator is a protein that in humans is encoded by the HGFAC gene. The protein ...
The dCas9 activation system allows a desired gene or multiple genes in the same cell to be expressed. It is possible to study genes involved in a certain process using a genome wide screen that involves activating expression of genes. Examining which sgRNAs yield a phenotype suggests which genes are involved in a specific pathway.
The SCF complex targets the 155 kDa full length Ci protein for proteosome-dependent cleavage, which generates a 75 kDa fragment (CiR). CiR builds up in the cell and diffuses into the nucleus , where it acts as a co- repressor for Hedgehog ( Hh ) target genes. [ 8 ]
Dishevelled-associated activator of morphogenesis 1 is a protein that in humans is encoded by the DAAM1 gene. [ 5 ] [ 6 ] [ 7 ] Evidence of alternative splicing has been observed for this gene but the full-length nature of these variants has not been determined.
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Activation by pH; Acidic conditions can denature the LAP. Treatment of the medium with extremes of pH (1.5 or 12) resulted in significant activation of TGF beta as shown by radio-receptor assays, while mild acid treatment (pH 4.5) yielded only 20-30% of the competition achieved by pH 1.5. [16] Activation reactive oxygen species (ROS)