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Transcriptional repressor CTCF also known as 11-zinc finger protein or CCCTC-binding factor is a transcription factor that in humans is encoded by the CTCF gene. [ 5 ] [ 6 ] CTCF is involved in many cellular processes, including transcriptional regulation , insulator activity, V(D)J recombination [ 7 ] and regulation of chromatin architecture.
Moreover, CTCF and cohesin play important roles in determining TADs and enhancer-promoter interactions. The result shows that the orientation of CTCF binding motifs in an enhancer-promoter loop should be facing to each other in order for the enhancer to find its correct target.
The key variables for (credit) risk assessment are the probability of default (PD), the loss given default (LGD) and the exposure at default (EAD).The credit conversion factor calculates the amount of a free credit line and other off-balance-sheet transactions (with the exception of derivatives) to an EAD amount [2] and is an integral part in the European banking regulation since the Basel II ...
RExcel is an add-on for Microsoft Excel that allows access to the statistics package R from within Excel. It uses the statconnDCOM server and, for certain configurations, the room package. RExcel runs on Microsoft Windows (XP, Vista, or 7), with Excel 2003, 2007, 2010, and 2013. [1]
It's no secret that Trader Joe's is a haven of savory dishes, sweet eats, snacks, and seasonal treats–and appetizers are no exception. With so many options to consider–from hummus to mac-and ...
A new study suggests that diets high in fast food, processed red meat, and soda but low in fruits and vegetables may be linked to faster biological aging.
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At this locus, CTCF functions as an insulator-binding protein forming a chromosomal boundary. [13] CTCF is present in both the chicken β-globin locus and human β-globin locus. Within cHS4 of the chicken β-globin locus, CTCF binds to a region (FII) that is responsible for enhancer blocking activity. [5]
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