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The side effects of bicalutamide, a nonsteroidal antiandrogen (NSAA), including its frequent and rare side effects, have been well-studied and characterized. The most common side effects of bicalutamide monotherapy in men include breast tenderness, breast growth, feminization, demasculinization, and hot flashes.
Bicalutamide is used primarily in the treatment of early and advanced prostate cancer. [1] It is approved at a dosage of 50 mg/day as a combination therapy with a gonadotropin-releasing hormone analogue (GnRH analogue) or orchiectomy (that is, surgical or medical castration) in the treatment of stage D2 metastatic prostate cancer (mPC), [2] [3] and as a monotherapy at a dosage of 150 mg/day ...
Bicalutamide is a diarylpropionamide while flutamide is a monoarylpropionamide and nilutamide is a hydantoin. [255] Bicalutamide and flutamide, though not nilutamide, can also be classified as toluidides. [247] All three of the compounds share a common 3-trifluoromethyl aniline moiety. [256]
Diabetes Medications as Weight Loss Treatments. Losing weight can be a significant priority for those with overweight and obesity. Carrying excess body weight can lead to medical conditions like ...
However, bicalutamide is the most potent of the three, with the highest affinity for the AR [23] [24] and the longest elimination half-life, [10] and is the safest, least toxic, and best-tolerated. [25] For these reasons, bicalutamide has largely replaced flutamide and nilutamide in clinical use, [26] and is by far the most widely used first ...
Trans fats occur when hydrogen is added to vegetable oil. The cholesterol-raising fat appears in many processed foods because it creates a lasting shelf life, but the FDA has.
The pharmacology of bicalutamide is the study of the pharmacodynamic and pharmacokinetic properties of the nonsteroidal antiandrogen (NSAA) bicalutamide.In terms of pharmacodynamics, bicalutamide acts as a selective antagonist of the androgen receptor (AR), the biological target of androgens like testosterone and dihydrotestosterone (DHT).
A specific type of body fat — visceral fat — around the midsection has been linked to the abnormal proteins that develop in the brain and are a hallmark of Alzheimer’s, according to findings ...