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Between 70%-98% of Hamito-Semitic groups in Ethiopia were found to be Duffy-positive. [59] Serological and DNA based analysis of 115 unrelated Tunisians also found an FY*X frequency of 0.0174; FY*1 = 0.291 (expressed 0.260, silent 0.031); FY*2 = 0.709 (expressed 0.427; silent 0.282). Since the FY*2 silent is the most common allele in West ...
HL-A1 antiserum reacts to HLA-A1 gene product, a cell surface antigen, the similar cell surface antigens are found on almost all cells in the body. The frequency of HLA-A1 alleles is: HLA-A1*0101- 17.3%, *0103- 0.016%. The frequency of *0101 is 1000 times more abundant than *0103, or 99.9% of the time you have identified the correct allele with ...
MHC Class II molecules are a class of major histocompatibility complex (MHC) molecules normally found only on professional antigen-presenting cells such as dendritic cells, macrophages, some endothelial cells, thymic epithelial cells, and B cells. These cells are important in initiating immune responses.
Complementarity-determining regions (CDRs) are polypeptide segments of the variable chains in immunoglobulins (antibodies) and T cell receptors, generated by B-cells and T-cells respectively. CDRs are where these molecules bind to their specific antigen and their structure/sequence determines the binding activity of the respective antibody.
The major histocompatibility complex (MHC) is a large locus on vertebrate DNA containing a set of closely linked polymorphic genes that code for cell surface proteins essential for the adaptive immune system. These cell surface proteins are called MHC molecules. Its name comes from its discovery during the study of transplanted tissue ...
The Ii antigen system is a human blood group system based upon a gene on chromosome 6 and consisting of the I antigen and the i antigen. [1] The I antigen is normally present on the cell membrane of red blood cells in all adults, while the i antigen is present in fetuses and newborns. [2]
Melanotransferrin (MFI2). This protein is a cell-surface glycoprotein found on melanoma cells CD229: LY9 - T-lymphocyte surface antigen; SLAMF3 CD230: PRNP - Major prion protein or PrP, for prion protein or protease-resistant protein). More than 20 mutations in the PRNP gene have been identified in people with inherited prion diseases. CD231
V(D)J recombination (variable–diversity–joining rearrangement) is the mechanism of somatic recombination that occurs only in developing lymphocytes during the early stages of T and B cell maturation. It results in the highly diverse repertoire of antibodies/immunoglobulins and T cell receptors (TCRs) found in B cells and T cells, respectively.