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The idea of epigenetics and gene expression has been a theory applied to the origins of homosexuality in humans. One team of researchers examined the effects of epi-marks buffering XX fetuses and XY fetuses from certain androgen exposure and used published data on fetal androgen signaling and gene regulation through non-genetic changes in DNA ...
This was popularly dubbed the "gay gene" in the media, causing significant controversy. In 1998, Sanders et al. [citation needed] reported on their similar study, in which they found that 13% of uncles of gay brothers on the maternal side were homosexual, compared with 6% on the paternal side. [33]
One was an X chromosome linkage analysis of 54 pairs of gay brothers carried out by the independent research group of Sanders et al. in 1998. The results of the study were indistinguishable from the results of the study by Hu et al. : both reported that the chromosomal location of maximum sharing was locus DXS1108 and both reported similar ...
The fraternal birth order effect has been described by one of its proponents as "the most consistent biodemographic correlate of sexual orientation in men". [5] In 1958, it was reported that homosexual men tend to have a greater number of older siblings (i.e., a 'later/higher birth order') than comparable heterosexual men and in 1962, these findings were published in detail. [6]
Despite numerous attempts, no "gay gene" has been identified. However, there is substantial evidence for a genetic basis of homosexuality, especially in males, based on twin studies; some association with regions of Chromosome 8, the Xq28 locus on the X chromosome, and other sites across many chromosomes. [170
Dean Hamer (/ ˈ h eɪ m ər /; born May 29, 1951) is an American geneticist, author, and filmmaker.He is known for his research on the role of genetics in sexual orientation and for a series of popular books and films that have changed scientific and public understandings and perceptions of human sexuality and gender.
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This supports the theory that the prenatal testosterone surge is crucial for gender identity development. Additionally, females whose mothers were exposed to diethylstilbestrol (DES) during pregnancy show higher rates of bi- and homosexuality. [4] Variations in the hypothalamus may have some influence on sexual orientation.